Reactome Pathway Database

Schema > BlackBoxEvent > Entries

SHC1 mediates cytokine-induced phosphorylation of GAB2 Show undefined attributes

category omitted

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10002650

displayName SHC1 mediates cytokine-induced phosphorylation of GAB2

eventOf

[Pathway:R-MMU-912526] Interleukin receptor SHC signaling - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases - Mus musculus

inferredFrom

[BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

SHC1 mediates cytokine-induced phosphorylation of GAB2

output

precedingEvent

[BlackBoxEvent:R-MMU-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Mus musculus

releaseDate 2025年09月18日

schemaClass BlackBoxEvent

species

[Species:48892] Mus musculus

stId R-MMU-912527

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-912526] Interleukin receptor SHC signaling

(precedingEvent)

[Reaction:R-MMU-508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases

(inferredTo)

[BlackBoxEvent:R-HSA-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2

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