Reactome Pathway Database

Schema > BlackBoxEvent > Entries

Phosphorylated SHC1 recruits GRB2:GAB2 Show undefined attributes

category omitted

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10000332

displayName Phosphorylated SHC1 recruits GRB2:GAB2

eventOf

[Pathway:R-MMU-912526] Interleukin receptor SHC signaling - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-MMU-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Mus musculus

inferredFrom

[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Phosphorylated SHC1 recruits GRB2:GAB2

output

[DefinedSet:R-MMU-912537] Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass BlackBoxEvent

species

[Species:48892] Mus musculus

stId R-MMU-453104

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-912526] Interleukin receptor SHC signaling

(precedingEvent)

[BlackBoxEvent:R-MMU-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2

(inferredTo)

[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2

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