Reactome Pathway Database

Schema > Reaction > Entries

RAB5 and GAPVD1 bind AP-2 Show undefined attributes

category binding

compartment

[Compartment:24339] clathrin-coated endocytic vesicle membrane

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10062187

displayName RAB5 and GAPVD1 bind AP-2

eventOf

[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[BlackBoxEvent:R-MMU-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2 - Mus musculus

inferredFrom

[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

RAB5 and GAPVD1 bind AP-2

output

[Complex:R-MMU-8871149] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]

precedingEvent

[Reaction:R-MMU-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-8871194

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-8856828] Clathrin-mediated endocytosis

(precedingEvent)

[BlackBoxEvent:R-MMU-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2

(inferredTo)

[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2

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