Reactome Pathway Database

Schema > Reaction > Entries

PAK1-3 dimer disassociates Show undefined attributes

category dissociation

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10036736

displayName PAK1-3 dimer disassociates

eventOf

[Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-MMU-5357472] PAK1-3 autophosphorylates - Mus musculus

inferredFrom

[Reaction:R-HSA-5357445] PAK1-3 dimer disassociates - Homo sapiens

input

[Complex:R-MMU-5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]

isInDisease false

isInferred true

maxDepth 1

name

PAK1-3 dimer disassociates

output

2 × [Complex:R-MMU-5357487] p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]

precedingEvent

[Reaction:R-MMU-5357483] RAC1 binds PAK1-3 - Mus musculus

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-5357445

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability

(precedingEvent)

[Reaction:R-MMU-5357472] PAK1-3 autophosphorylates

(inferredTo)

[Reaction:R-HSA-5357445] PAK1-3 dimer disassociates

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