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PAK1-3 dimer disassociates Show undefined attributes

authored

[InstanceEdit:4420157] Garapati, P V, 2013年08月30日

category dissociation

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:5357434] Garapati, P V, 2014年03月21日

dbId 5357445

displayName PAK1-3 dimer disassociates

edited

[InstanceEdit:4420157] Garapati, P V, 2013年08月30日

eventOf

[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens

followingEvent

[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates - Homo sapiens

input

[Complex:R-HSA-5357447] 2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:2028849] Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

PAK1-3 dimer disassociates

orthologousEvent

output

2 × [Complex:R-HSA-5357487] p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]

precedingEvent

[Reaction:R-HSA-5357483] RAC1 binds PAK1-3 - Homo sapiens

releaseDate 2014年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014年05月12日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-5357445

summation

[Summation:5357438] Binding of Rac1 increases p21 activated kinases 1-3 (PAK1-3)...

Referrals

(hasEvent)

[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability

(precedingEvent)

[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates

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