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Schema
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Reaction
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Entries
DLAT trimer transfers acetyl to CoA
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authored
[InstanceEdit:9861713] Stephan, Ralf, 2024年01月25日
catalystActivity
[CatalystActivity:9861662] dihydrolipoyllysine-residue acetyltransferase activity of PDH complex [mitochondrial matrix]
category
transition
compartment
[Compartment:70616] mitochondrial inner membrane
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:9861650] Stephan, Ralf, 2024年02月21日
crossReference
[DatabaseIdentifier:9861618] RHEA:17019
dbId
9861667
displayName
DLAT trimer transfers acetyl to CoA
edited
[InstanceEdit:9861650] Stephan, Ralf, 2024年02月21日
eventOf
[Pathway:R-HSA-9861559] PDH complex synthesizes acetyl-CoA from PYR - Homo sapiens
followingEvent
[Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1 - Homo sapiens
[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-9861594] AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix]
[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9861582] Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex
[LiteratureReference:9861648] Primary structure of the human M2 mitochondrial autoantigen of primary biliary cirrhosis: dihydrolipoamide acetyltransferase
[LiteratureReference:450841] Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
DLAT trimer transfers acetyl to CoA
orthologousEvent
[Reaction:R-MMU-9861667] DLAT trimer transfers acetyl to CoA - Mus musculus
[Reaction:R-DME-9861667] DLAT trimer transfers acetyl to CoA - Drosophila melanogaster
[Reaction:R-RNO-9861667] DLAT trimer transfers acetyl to CoA - Rattus norvegicus
[Reaction:R-DDI-9861667] DLAT trimer transfers acetyl to CoA - Dictyostelium discoideum
[Reaction:R-GGA-9861667] DLAT trimer transfers acetyl to CoA - Gallus gallus
[Reaction:R-SSC-9861667] DLAT trimer transfers acetyl to CoA - Sus scrofa
[Reaction:R-BTA-9861667] DLAT trimer transfers acetyl to CoA - Bos taurus
[Reaction:R-CFA-9861667] DLAT trimer transfers acetyl to CoA - Canis familiaris
[Reaction:R-XTR-9861667] DLAT trimer transfers acetyl to CoA - Xenopus tropicalis
[Reaction:R-SCE-9861667] DLAT trimer transfers acetyl to CoA - Saccharomyces cerevisiae
[Reaction:R-SPO-9861667] DLAT trimer transfers acetyl to CoA - Schizosaccharomyces pombe
[Reaction:R-CEL-9861667] DLAT trimer transfers acetyl to CoA - Caenorhabditis elegans
output
[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix]
[EntityWithAccessionedSequence:R-HSA-9861664] LipoH2-K259-DLAT [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens
[Reaction:R-HSA-204169] PDP1,2 dephosphorylate p-lipo-PDH - Homo sapiens
regulatedBy
[NegativeRegulation:9861545] Negative regulation by 'DLAT [mitochondrial matrix]'
regulationReference
[RegulationReference:9861682] Negative regulation by 'DLAT [mitochondrial matrix]' Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
releaseDate
2024年03月27日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9862191] Hill, David P, 2024年02月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9861667
summation
[Summation:9861554] Dihydrolipoyllysine-residue acetyltransferase (DLAT, PDHE2),...
Referrals
(hasEvent)
[Pathway:R-HSA-9861559] PDH complex synthesizes acetyl-CoA from PYR
(precedingEvent)
[Reaction:R-HSA-203946] PDK isozymes phosphorylate PDHC subunit E1
[Reaction:R-HSA-70501] PC carboxylates PYR to OA
[Reaction:R-HSA-9861616] DLD dimer dehydrogenates dihydrolipoyl
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