Reactome | Growth hormone receptor dimerizes

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Growth hormone receptor dimerizes Show undefined attributes

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authored

[InstanceEdit:976955] Jupe, S, 2010年10月14日

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:982796] Jupe, S, 2010年10月28日

dbId 982775

displayName Growth hormone receptor dimerizes

edited

[InstanceEdit:1362504] Jupe, S, 2011年06月10日

eventOf

[Pathway:R-HSA-982772] Growth hormone receptor signaling - Homo sapiens

followingEvent

[Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor - Homo sapiens

input

2 × [Complex:R-HSA-982774] Growth Hormone Receptor:JAK2 [plasma membrane]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:982786] Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

maxDepth 1

modified [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

name

Growth hormone receptor dimerizes

orthologousEvent

output

[Complex:R-HSA-982764] Growth Hormone Receptor-JAK2 dimer [plasma membrane]

precedingEvent

[Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 - Homo sapiens

regulatedBy

[NegativeRegulation:R-HSA-1362495] Negative regulation by 'GHBP:GHR [plasma membrane]'

regulationReference

[RegulationReference:9642925] Negative regulation by 'GHBP:GHR [plasma membrane]' A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein

releaseDate 2011年09月20日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-982775

summation

[Summation:982800] The growth hormone receptor forms dimers (Cunningham et al. ...

updateTrackers

[UpdateTracker:9775869] Update Tracker - [Reaction:982775] Growth hormone receptor dimerizes - v78:[modifyText]

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(updatedInstance)

[UpdateTracker:9775869] Update Tracker - [Reaction:982775] Growth hormone receptor dimerizes - v78:[modifyText]

(hasEvent)

[Pathway:R-HSA-982772] Growth hormone receptor signaling

(precedingEvent)

[Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor

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Growth hormone receptor dimerizes Show undefined attributes

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