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Entries
Growth hormone receptor signaling
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authored
[InstanceEdit:976955] Jupe, S, 2010年10月14日
compartment
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:982796] Jupe, S, 2010年10月28日
crossReference
[DatabaseIdentifier:12758186] BioModels Database:BIOMD0000001077
[DatabaseIdentifier:12758188] BioModels Database:BIOMD0000000314
[DatabaseIdentifier:12758190] BioModels Database:BIOMD0000000313
dbId
982772
displayName
Growth hormone receptor signaling
edited
[InstanceEdit:1362504] Jupe, S, 2011年06月10日
eventOf
[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:396537] growth hormone receptor signaling pathway via JAK-STAT
hasDiagram
true
hasEHLD
false
hasEvent
[Polymerisation:R-HSA-982765] Growth hormone forms dimers and oligomers - Homo sapiens
[Reaction:R-HSA-982792] Growth hormone receptor binds JAK2 - Homo sapiens
[Reaction:R-HSA-982775] Growth hormone receptor dimerizes - Homo sapiens
[Reaction:R-HSA-982778] Growth hormone binds the growth hormone receptor - Homo sapiens
[BlackBoxEvent:R-HSA-982768] GH:GHR:JAK2 complex undergoes a conformational change - Homo sapiens
[BlackBoxEvent:R-HSA-982810] JAK2 phosphorylation - Homo sapiens
[Reaction:R-HSA-1168423] JAK2 phosphorylation of IRS-1/2 - Homo sapiens
[Reaction:R-HSA-982807] JAK2 phosphorylation of GHR - Homo sapiens
[Reaction:R-HSA-1168393] STAT5 association with GHR - Homo sapiens
[Reaction:R-HSA-1168394] STAT5 tyrosine phosphorylation - Homo sapiens
[Reaction:R-HSA-1168894] p-STAT5A/B dissociates from the Growth Hormone receptor - Homo sapiens
[Reaction:R-HSA-452102] p-STAT5 dimerizes - Homo sapiens
[BlackBoxEvent:R-HSA-507937] STAT5 dimers translocate to the nucleus - Homo sapiens
[Reaction:R-HSA-1168456] Growth hormone receptor binds Lyn - Homo sapiens
[BlackBoxEvent:R-HSA-1168459] Lyn activates ERK - Homo sapiens
[Reaction:R-HSA-1168768] JAK2 binds STAT1/3 - Homo sapiens
[Reaction:R-HSA-1168767] JAK2 phosphorylates STAT1/STAT3 - Homo sapiens
[Reaction:R-HSA-1168809] SOCS binding to GHR - Homo sapiens
[Reaction:R-HSA-1168813] SOCS binding to JAK2 - Homo sapiens
[Reaction:R-HSA-1168445] PTP1B binds the GH receptor complex - Homo sapiens
[Reaction:R-HSA-1169192] PTP1B dephosphorylates GHR - Homo sapiens
[Reaction:R-HSA-1169210] PTP1B dephosphorylates JAK2 - Homo sapiens
[Reaction:R-HSA-1168839] SHP1 (PTPN6) binds JAK2 in the receptor complex - Homo sapiens
[Reaction:R-HSA-1169188] SHP1 (PTPN6) dephosphorylates JAK2 - Homo sapiens
[Reaction:R-HSA-1168777] Metalloprotease cleavage of GHR - Homo sapiens
[Reaction:R-HSA-1362485] GHBP binds GH - Homo sapiens
[Reaction:R-HSA-1362465] GHBP binds GHR - Homo sapiens
[BlackBoxEvent:R-HSA-1168789] GHR internalization - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:1168415] The growth hormone receptor: mechanism of activation and clinical implications
[LiteratureReference:982825] Growth hormone receptor: structure and signal transduction
[LiteratureReference:982766] In vivo analysis of growth hormone receptor signaling domains and their associated transcripts
[LiteratureReference:1169265] Determinants of growth hormone receptor down-regulation
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Growth hormone receptor signaling
orthologousEvent
[Pathway:R-MMU-982772] Growth hormone receptor signaling - Mus musculus
[Pathway:R-RNO-982772] Growth hormone receptor signaling - Rattus norvegicus
[Pathway:R-CFA-982772] Growth hormone receptor signaling - Canis familiaris
[Pathway:R-BTA-982772] Growth hormone receptor signaling - Bos taurus
[Pathway:R-SSC-982772] Growth hormone receptor signaling - Sus scrofa
[Pathway:R-DRE-982772] Growth hormone receptor signaling - Danio rerio
[Pathway:R-XTR-982772] Growth hormone receptor signaling - Xenopus tropicalis
[Pathway:R-GGA-982772] Growth hormone receptor signaling - Gallus gallus
[Pathway:R-CEL-982772] Growth hormone receptor signaling - Caenorhabditis elegans
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1363241] Herington, AC, 2011年06月13日
[InstanceEdit:1364056] Waters, MJ, 2011年06月23日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-982772
summation
[Summation:1169268] Growth hormone (Somatotropin or GH) is a key factor in deter...
updateTrackers
[UpdateTracker:9789003] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v39:[updateContainedRLE]
[UpdateTracker:9775936] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v78:[updateContainedRLE]
[UpdateTracker:9779194] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v66:[updateContainedRLE]
[UpdateTracker:9788604] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v41:[updateContainedRLE]
[UpdateTracker:9787042] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v46:[updateContainedRLE]
[UpdateTracker:9780242] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v63:[updateContainedRLE]
[UpdateTracker:9781454] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v61:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system
(updatedInstance)
[UpdateTracker:9789003] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v39:[updateContainedRLE]
[UpdateTracker:9775936] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v78:[updateContainedRLE]
[UpdateTracker:9779194] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v66:[updateContainedRLE]
[UpdateTracker:9788604] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v41:[updateContainedRLE]
[UpdateTracker:9787042] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v46:[updateContainedRLE]
[UpdateTracker:9780242] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v63:[updateContainedRLE]
[UpdateTracker:9781454] Update Tracker - [Pathway:982772] Growth hormone receptor signaling - v61:[updateContainedRLE]
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