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Schema
>
Reaction
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Entries
EOMES, SMAD2,3, MIXL1 bind the GSC gene
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authored
[InstanceEdit:9823884] May, Bruce, 2023年01月11日
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9823972] May, Bruce, 2023年01月13日
dbId
9823966
displayName
EOMES, SMAD2,3, MIXL1 bind the GSC gene
edited
[InstanceEdit:9823884] May, Bruce, 2023年01月11日
eventOf
[Pathway:R-HSA-9823730] Formation of definitive endoderm - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9823992] Expression of GSC in definitive endoderm - Homo sapiens
inferredFrom
[Reaction:R-MMU-9823983] Mixl1 binds the Gsc gene - Mus musculus
input
[EntityWithAccessionedSequence:R-HSA-452232] EOMES [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2888980] GSC gene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9758510] MIXL1 [nucleoplasm]
[DefinedSet:R-HSA-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
true
literatureReference
[LiteratureReference:2975839] Pluripotency factors regulate definitive endoderm specification through eomesodermin
[LiteratureReference:2888922] Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors
[LiteratureReference:9824500] DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells
maxDepth
1
modified
[InstanceEdit:9830227] May, Bruce, 2023年02月28日
name
EOMES, SMAD2,3, MIXL1 bind the GSC gene
output
[Complex:R-HSA-9823985] EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm]
precedingEvent
[BlackBoxEvent:R-HSA-9758501] Expression of MIXL1 in the primitive streak - Homo sapiens
[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
[BlackBoxEvent:R-HSA-452353] Expression of EOMES in the primitive streak - Homo sapiens
releaseDate
2023年03月29日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9830224] Salehin, Nazmus, 2023年02月28日
[InstanceEdit:9830223] Tam, Patrick P L, 2023年02月28日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9823966
summation
[Summation:9825036] NODAL signaling causes the phosphorylation of SMAD2 and SMAD...
Referrals
(precedingEvent)
[BlackBoxEvent:R-HSA-9823992] Expression of GSC in definitive endoderm
(hasEvent)
[Pathway:R-HSA-9823730] Formation of definitive endoderm
(inferredTo)
[Reaction:R-MMU-9823983] Mixl1 binds the Gsc gene
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