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Entries
Formation of definitive endoderm
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authored
[InstanceEdit:9823732] May, Bruce, 2023年01月08日
created
[InstanceEdit:9823728] May, Bruce, 2023年01月08日
crossReference
[DatabaseIdentifier:12758132] BioModels Database:BIOMD0000000997
[DatabaseIdentifier:12758134] BioModels Database:BIOMD0000000342
[DatabaseIdentifier:12758136] BioModels Database:BIOMD0000001001
[DatabaseIdentifier:12758138] BioModels Database:BIOMD0000001003
[DatabaseIdentifier:12758140] BioModels Database:BIOMD0000000989
[DatabaseIdentifier:12758142] BioModels Database:BIOMD0000000499
[DatabaseIdentifier:12758144] BioModels Database:BIOMD0000000995
[DatabaseIdentifier:12758146] BioModels Database:BIOMD0000000173
[DatabaseIdentifier:12758148] BioModels Database:BIOMD0000000998
[DatabaseIdentifier:12758150] BioModels Database:BIOMD0000000996
[DatabaseIdentifier:12758152] BioModels Database:BIOMD0000000990
[DatabaseIdentifier:12758154] BioModels Database:BIOMD0000001000
[DatabaseIdentifier:12758156] BioModels Database:BIOMD0000000999
[DatabaseIdentifier:12758160] BioModels Database:BIOMD0000001002
[DatabaseIdentifier:12758162] BioModels Database:BIOMD0000000994
dbId
9823730
displayName
Formation of definitive endoderm
doi
10.3180/R-HSA-9823730.1
edited
[InstanceEdit:9823732] May, Bruce, 2023年01月08日
eventOf
[Pathway:R-HSA-9758941] Gastrulation - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:2186] endoderm formation
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9823958] EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823989] Expression of FOXA2 in definitive endoderm - Homo sapiens
[Reaction:R-HSA-9823959] SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823977] Expression of GATA6 in definitive endoderm - Homo sapiens
[Reaction:R-HSA-9824472] TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823729] Expression of SOX17 in definitive endoderm - Homo sapiens
[Reaction:R-HSA-9823836] SMAD2,3, FOXA2, TBXT, and GATA6 bind the GATA4 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823849] Expression of GATA4 in definitive endoderm - Homo sapiens
[Reaction:R-HSA-9823966] EOMES, SMAD2,3, MIXL1 bind the GSC gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823992] Expression of GSC in definitive endoderm - Homo sapiens
[Reaction:R-HSA-9823952] EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene - Homo sapiens
[BlackBoxEvent:R-HSA-9823950] Expression of CXCR4 in definitive endoderm - Homo sapiens
[BlackBoxEvent:R-HSA-9823995] Expression of E-cadherin (CDH1) in definitive endoderm - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9754502] Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
[LiteratureReference:9823982] GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation
[LiteratureReference:9794959] Pluripotency factors in embryonic stem cells regulate differentiation into germ layers
[LiteratureReference:9823981] Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells
[LiteratureReference:9824482] The endoderm: a divergent cell lineage with many commonalities
[LiteratureReference:9823949] SOX17 links gut endoderm morphogenesis and germ layer segregation
[LiteratureReference:9824461] Definitive endoderm of the mouse embryo: formation, cell fates, and morphogenetic function
[LiteratureReference:9758910] Epithelial cell plasticity drives endoderm formation during gastrulation
[LiteratureReference:9827621] Cell fate decisions within the mouse organizer are governed by graded Nodal signals
[LiteratureReference:9827620] The organizer factors Chordin and Noggin are required for mouse forebrain development
[LiteratureReference:9827605] Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse
[LiteratureReference:9827846] Efficient differentiation of human embryonic stem cells to definitive endoderm
[LiteratureReference:9830208] Spatial profiling of early primate gastrulation in utero
[LiteratureReference:9830203] Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation
maxDepth
2
modified
[InstanceEdit:9830345] Wright, Adam, 2023年03月08日
name
Formation of definitive endoderm
releaseDate
2023年03月29日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9830224] Salehin, Nazmus, 2023年02月28日
[InstanceEdit:9830223] Tam, Patrick P L, 2023年02月28日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9823730
summation
[Summation:9823872] The endoderm in mammalian embryos originates from two differ...
updateTrackers
[UpdateTracker:9928466] Update Tracker - [Pathway:9823730] Formation of definitive endoderm - v91:[modifyText]
Referrals
(hasEvent)
[Pathway:R-HSA-9758941] Gastrulation
(updatedInstance)
[UpdateTracker:9928466] Update Tracker - [Pathway:9823730] Formation of definitive endoderm - v91:[modifyText]
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