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Entries
Regulation of Complement cascade
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authored
[InstanceEdit:981647] Jupe, S, 2010年10月26日
compartment
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:977612] Jupe, S, 2010年10月20日
crossReference
[DatabaseIdentifier:12758192] BioModels Database:BIOMD0000000303
dbId
977606
displayName
Regulation of Complement cascade
doi
10.3180/R-HSA-977606.3
edited
[InstanceEdit:983442] Jupe, S, 2010年11月01日
eventOf
[Pathway:R-HSA-166658] Complement cascade - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:23338] regulation of complement activation
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-981621] C3 convertases spontaneously dissociate - Homo sapiens
[Reaction:R-HSA-976768] Factor H binds to C3b - Homo sapiens
[Reaction:R-HSA-1006169] Factor H binds host cell surface markers - Homo sapiens
[Reaction:R-HSA-981728] Factor H binds to membrane-associated C3b - Homo sapiens
[Reaction:R-HSA-977363] Factor H binds to C3bBb - Homo sapiens
[Reaction:R-HSA-977605] Factor H displaces Bb - Homo sapiens
[Reaction:R-HSA-8851436] CFHR dimers bind C3b - Homo sapiens
[Reaction:R-HSA-976801] Complement factor I complex formation - Homo sapiens
[Reaction:R-HSA-976810] Complement factor I binds to extracellular Factor H:C3b - Homo sapiens
[Reaction:R-HSA-976743] Factor I inactivates plasma Factor H-bound C3b - Homo sapiens
[Reaction:R-HSA-977359] Complement factor I binds to membrane-associated Factor H:C3b - Homo sapiens
[Reaction:R-HSA-977371] Factor I inactivates Factor H-boundC3b - Homo sapiens
[Reaction:R-HSA-3266557] Factor I cleaves iC3b - Homo sapiens
[Reaction:R-HSA-977375] CR1 binds C3bBb/C4bC2a - Homo sapiens
[Reaction:R-HSA-977629] Displacement of C2a/Bb by CR1 - Homo sapiens
[Reaction:R-HSA-8852874] CR2 binds C3d, C3dg, iC3b - Homo sapiens
[Reaction:R-HSA-8853252] CR2:C3d,C3dg,iC3b binds CD19:CD81 - Homo sapiens
[Reaction:R-HSA-1006143] CD46 binds C3b - Homo sapiens
[Reaction:R-HSA-8951486] CD46 binds C4b - Homo sapiens
[Reaction:R-HSA-977602] Complement factor I binds to MCP, CR1:C4b, C3b - Homo sapiens
[Reaction:R-HSA-977615] Factor I inactivates MCP/CR1-bound C4b/C3b - Homo sapiens
[Reaction:R-HSA-981535] CD55 (DAF) binds C3bBb, C4bC2a - Homo sapiens
[Reaction:R-HSA-977619] CD55 (DAF) promotes C3bBb/C4bC2a dissociation - Homo sapiens
[Reaction:R-HSA-977626] C4b-binding protein binds C4b - Homo sapiens
[Reaction:R-HSA-981658] Complement factor I binds C4BP - Homo sapiens
[Reaction:R-HSA-981637] Complement factor I inactivates C4BP-bound C4b - Homo sapiens
[BlackBoxEvent:R-HSA-981648] C4b binding protein binds C4bC2a - Homo sapiens
[BlackBoxEvent:R-HSA-981680] C4b binding protein displaces C2a - Homo sapiens
[Reaction:R-HSA-981665] C4b binding protein binds Protein S - Homo sapiens
[Reaction:R-HSA-2530445] CD59 inhibits MAC formation - Homo sapiens
[Reaction:R-HSA-2530429] Formation of soluble VTN:C5b-C9 - Homo sapiens
[Reaction:R-HSA-2530453] Vitronectin (VTN) binds to C5b:C6:C7 - Homo sapiens
[Reaction:R-HSA-2855047] Hydrolysis of internal thioester in C4b - Homo sapiens
[Reaction:R-HSA-8852266] C1-Inh binds Antigen: antibody: C1 complex activated C1r, C1s - Homo sapiens
[Reaction:R-HSA-9021306] C1-Inh binds and inactivates C1r, C1s - Homo sapiens
[Reaction:R-HSA-8852481] Antigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociates - Homo sapiens
[Reaction:R-HSA-444647] C3a receptor binds anaphylatoxin C3a - Homo sapiens
[Reaction:R-HSA-375395] C5a receptor binds C5a anaphylatoxin - Homo sapiens
[Reaction:R-HSA-964811] C5AR2 binds anaphylatoxins and thier desArginated derivatives - Homo sapiens
[Reaction:R-HSA-8852580] Clusterin binds C5b-C7, C8, C9 - Homo sapiens
[Reaction:R-HSA-8852716] Thrombin, ELANE cleave C5 - Homo sapiens
[Reaction:R-HSA-8852809] CPN, CPB2 cleave C3a, C5a - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2017年12月18日
literatureReference
[LiteratureReference:173683] Complement: a unique innate immune sensor for danger signals
[LiteratureReference:1990865] Complement regulators and inhibitory proteins
[LiteratureReference:983437] Complement: a key system for immune surveillance and homeostasis
[URL:981677] http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html
maxDepth
2
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Regulation of Complement cascade
orthologousEvent
[Pathway:R-DME-977606] Regulation of Complement cascade - Drosophila melanogaster
[Pathway:R-GGA-977606] Regulation of Complement cascade - Gallus gallus
[Pathway:R-XTR-977606] Regulation of Complement cascade - Xenopus tropicalis
[Pathway:R-DRE-977606] Regulation of Complement cascade - Danio rerio
[Pathway:R-SSC-977606] Regulation of Complement cascade - Sus scrofa
[Pathway:R-BTA-977606] Regulation of Complement cascade - Bos taurus
[Pathway:R-CFA-977606] Regulation of Complement cascade - Canis familiaris
[Pathway:R-RNO-977606] Regulation of Complement cascade - Rattus norvegicus
[Pathway:R-MMU-977606] Regulation of Complement cascade - Mus musculus
previousReviewStatus
[ReviewStatus:9821382] five stars
releaseDate
2012年03月13日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2109568] Bradley, DT, 2012年02月13日
[InstanceEdit:2109566] Fraczek, LA, 2012年02月13日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-977606
summation
[Summation:981528] Two inherent features of complement activation make its regu...
updateTrackers
[UpdateTracker:9788399] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v42:[updateContainedRLE]
[UpdateTracker:9783740] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9782299] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v59:[updateContainedRLE]
[UpdateTracker:9786575] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v49:[modifyText]
[UpdateTracker:9780268] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9787346] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v45:[addHasEvent, modifyText]
[UpdateTracker:9781634] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v60:[addHasEvent, updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-166658] Complement cascade
(updatedInstance)
[UpdateTracker:9788399] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v42:[updateContainedRLE]
[UpdateTracker:9783740] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9782299] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v59:[updateContainedRLE]
[UpdateTracker:9786575] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v49:[modifyText]
[UpdateTracker:9780268] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v63:[addHasEvent, updateContainedRLE]
[UpdateTracker:9787346] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v45:[addHasEvent, modifyText]
[UpdateTracker:9781634] Update Tracker - [Pathway:977606] Regulation of Complement cascade - v60:[addHasEvent, updateContainedRLE]
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