Reactome | Amyloid fiber formation

authored

[InstanceEdit:977142] Jupe, S, 2010年10月15日

created [InstanceEdit:977222] Jupe, S, 2010年10月15日

dbId 977225

displayName Amyloid fiber formation

doi 10.3180/r-hsa-977225.3

edited

[InstanceEdit:1247884] Jupe, S, 2011年04月08日

eventOf

[TopLevelPathway:R-HSA-392499] Metabolism of proteins - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:3132675] amyloid fibril formation

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-HSA-5658092] SIAH1, SIAH2 bind SNCAIP - Homo sapiens
[BlackBoxEvent:R-HSA-5667107] SIAH1, SIAH2 ubiquitinate SNCAIP - Homo sapiens
[Reaction:R-HSA-5658574] PARK2 binds SNCAIP - Homo sapiens
[BlackBoxEvent:R-HSA-5667111] PARK2 K63-Ubiquitinates SNCAIP - Homo sapiens
[Reaction:R-HSA-5658496] SIAH1:UBE2L6:Ubiquitin binds SNCA - Homo sapiens
[Reaction:R-HSA-5660753] SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA - Homo sapiens
[BlackBoxEvent:R-HSA-5660757] Ub-SNCA dissociates from the conjugating enzyme - Homo sapiens
[Reaction:R-HSA-5661157] USP9X binds Ub-SNCA - Homo sapiens
[Reaction:R-HSA-5660752] USP9X deubiquitinates Ub-SNCA - Homo sapiens
[Reaction:R-HSA-5661161] USP9X:SNCA dissociates - Homo sapiens
[Reaction:R-HSA-5658104] SNCAIP binds alpha-synuclein - Homo sapiens
[Reaction:R-HSA-976723] Serum amyloid P-component forms homopentamers - Homo sapiens
[Reaction:R-HSA-5693001] NAT8,8B acetylate BACE1 - Homo sapiens
[BlackBoxEvent:R-HSA-5693071] BACE1 translocates from ER lumen to Golgi apparatus - Homo sapiens
[BlackBoxEvent:R-HSA-5693081] FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501) - Homo sapiens
[BlackBoxEvent:R-HSA-5693092] Unknown deacetylase deacetylates 7K-BACE1(46-501) - Homo sapiens
[BlackBoxEvent:R-HSA-5693086] BACE1(46-501) translocates from Golgi lumen to plasma membrane - Homo sapiens
[Reaction:R-HSA-5692934] BACE1 binds GGA1,2,3 - Homo sapiens
[Reaction:R-HSA-5692941] BACE1:GGA1,2,3 translocates from plasma membrane to endosome - Homo sapiens
[Reaction:R-HSA-5692495] BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770) - Homo sapiens
[Reaction:R-HSA-9010096] Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) - Homo sapiens
[BlackBoxEvent:R-HSA-6783332] APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region - Homo sapiens
[Reaction:R-HSA-8871494] SORL1 binds APP(18-770) - Homo sapiens
[Reaction:R-HSA-8871506] SORL1 transports APP(18-770) from endosome lumen to Golgi lumen - Homo sapiens
[Polymerisation:R-HSA-977136] Amyloid precursor proteins form ordered fibrils - Homo sapiens
[Reaction:R-HSA-976734] Amyloid fibrils have additional components - Homo sapiens
[Reaction:R-HSA-976817] Formation of serum amyloid P decamer - Homo sapiens
[Reaction:R-HSA-977224] Serum amyloid P binds DNA and chromatin - Homo sapiens
[Reaction:R-HSA-8932599] CALB1 binds 4xCa2+ - Homo sapiens
[Reaction:R-HSA-9010113] ADAM10:Zn2+ binds TSPANs - Homo sapiens
[BlackBoxEvent:R-HSA-9010074] ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane - Homo sapiens
[Reaction:R-HSA-9010034] ADAM10:Zn2+:TSPANs cleaves APP(18-770) - Homo sapiens
[BlackBoxEvent:R-HSA-9010091] APP translocates from plasma membrane to endosome lumen - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2021年03月24日

literatureReference

[LiteratureReference:976859] Aspects on human amyloid forms and their fibril polypeptides

maxDepth 2

modified [InstanceEdit:9847082] Weiser, Joel, 2023年10月12日

name

Amyloid fiber formation

releaseDate 2011年06月14日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-977225

summation

[Summation:976920] Amyloid is a term used to describe deposits of fibrillar pro...

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