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Schema
>
Polymerisation
>
Entries
Amyloid precursor proteins form ordered fibrils
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authored
[InstanceEdit:977142] Jupe, S, 2010年10月15日
category
transition
compartment
[Compartment:984] extracellular region
created
[InstanceEdit:977142] Jupe, S, 2010年10月15日
crossReference
[DatabaseIdentifier:11944946] Mondo:0019065
dbId
977136
disease
[Disease:3322973] Amyloidosis
displayName
Amyloid precursor proteins form ordered fibrils
edited
[InstanceEdit:1247884] Jupe, S, 2011年04月08日
eventOf
[Pathway:R-HSA-977225] Amyloid fiber formation - Homo sapiens
followingEvent
[Reaction:R-HSA-976734] Amyloid fibrils have additional components - Homo sapiens
input
[DefinedSet:R-HSA-977175] Amyloid fibril monomers [extracellular region]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1247791] Pathogenic potential of human monoclonal immunoglobulin light chains: relationship of in vitro aggregation to in vivo organ deposition
[LiteratureReference:1247809] Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease
[LiteratureReference:1247702] Immunoglobulin heavy-chain-associated amyloidosis
[LiteratureReference:1247697] Serum levels of beta 2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis
[LiteratureReference:1247691] Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy
[LiteratureReference:1247711] Isolation and partial characterization of SAA-an amyloid-related protein from human serum
[LiteratureReference:976941] Variant apolipoprotein AI as a major constituent of a human hereditary amyloid
[LiteratureReference:976942] A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene
[LiteratureReference:976949] Codeposition of apolipoprotein A-IV and transthyretin in senile systemic (ATTR) amyloidosis
[LiteratureReference:976852] Gelsolin-related amyloidosis. Identification of the amyloid protein in Finnish hereditary amyloidosis as a fragment of variant gelsolin
[LiteratureReference:976877] Human lysozyme gene mutations cause hereditary systemic amyloidosis
[LiteratureReference:976921] Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain
[LiteratureReference:976879] Mutation in cystatin C gene causes hereditary brain haemorrhage
[LiteratureReference:976939] A stop-codon mutation in the BRI gene associated with familial British dementia
[LiteratureReference:1247724] Leukocyte chemotactic factor 2: A novel renal amyloid protein
[LiteratureReference:1247757] The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease
[LiteratureReference:1247784] Assignment of the human and mouse prion protein genes to homologous chromosomes
[LiteratureReference:976970] Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells
[LiteratureReference:1247766] Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation
[LiteratureReference:1247781] Atrial amyloid deposits in the failing human heart display both atrial and brain natriuretic peptide-like immunoreactivity
[LiteratureReference:976959] Prolactin-derived amyloid in the aging pituitary gland
[LiteratureReference:1247801] An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing
[LiteratureReference:977154] Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid
[LiteratureReference:977166] Kerato-epithelin mutations in four 5q31-linked corneal dystrophies
[LiteratureReference:1247709] Localized amyloidosis of the seminal vesicle: identification of lactoferrin immunoreactivity in the amyloid material
[LiteratureReference:1247717] Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles
[LiteratureReference:977189] Senile seminal vesicle amyloid is derived from semenogelin I
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Amyloid precursor proteins form ordered fibrils
output
[DefinedSet:R-HSA-977144] Amyloid fibril main peptide chains [extracellular region]
precedingEvent
[BlackBoxEvent:R-HSA-6783332] APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region - Homo sapiens
releaseDate
2011年06月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1247882] Perry, G, 2011年04月08日
[InstanceEdit:6809157] Perry, George, 2015年11月09日
schemaClass
Polymerisation
species
[Species:48887] Homo sapiens
stId
R-HSA-977136
summation
[Summation:977111] Amyloid fibril formation is associated with a wide range of ...
updateTrackers
[UpdateTracker:9783867] Update Tracker - [Polymerisation:977136] Amyloid precursor proteins form ordered fibrils - v55:[modifyText]
[UpdateTracker:9785072] Update Tracker - [Polymerisation:977136] Amyloid precursor proteins form ordered fibrils - v52:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9783867] Update Tracker - [Polymerisation:977136] Amyloid precursor proteins form ordered fibrils - v55:[modifyText]
[UpdateTracker:9785072] Update Tracker - [Polymerisation:977136] Amyloid precursor proteins form ordered fibrils - v52:[modifyText]
(hasEvent)
[Pathway:R-HSA-977225] Amyloid fiber formation
(precedingEvent)
[Reaction:R-HSA-976734] Amyloid fibrils have additional components
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