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Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane Show undefined attributes

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authored

[InstanceEdit:847735] Shamovsky, V, 2010年06月01日

catalystActivity

[CatalystActivity:1014251] ubiquitin-protein transferase activity of p-IRAK2:oligo-TRAF6 [endosome membrane]

category omitted

compartment

created [InstanceEdit:975168] Shamovsky, V, 2010年09月22日

dbId 975147

displayName Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

edited

[InstanceEdit:1014262] Shamovsky, V, 2010年11月15日

eventOf

[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Homo sapiens

followingEvent

input

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

maxDepth 1

modified [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

name

Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane

orthologousEvent

output

[Complex:R-HSA-975164] p-IRAK2:K63-linked pUb oligo-TRAF6 [endosome membrane]

precedingEvent

[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens

releaseDate 2010年12月14日

requiredInputComponent

[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:983288] Gillespie, ME, 2010年10月29日

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-975147

summation

[Summation:202446] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

(precedingEvent)

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