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Schema
>
BlackBoxEvent
>
Entries
COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
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authored
[InstanceEdit:9733215] Orlic-Milacic, Marija, 2021年06月01日
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9733215] Orlic-Milacic, Marija, 2021年06月01日
dbId
9733216
displayName
COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
edited
[InstanceEdit:9773649] Orlic-Milacic, Marija, 2022年05月09日
eventOf
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription - Homo sapiens
followingEvent
[Reaction:R-HSA-2002460] P4HB binds Collagen chains - Homo sapiens
[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Homo sapiens
[Reaction:R-HSA-8944214] Association of procollagen type I - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-6789344] COL1A2 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9733230] Interferon-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3
[LiteratureReference:9733228] Y-box-binding protein YB-1 mediates transcriptional repression of human alpha 2(I) collagen gene expression by interferon-gamma
[LiteratureReference:9733222] Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects
[LiteratureReference:9733236] Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
[LiteratureReference:9733245] Constitutively phosphorylated Smad3 interacts with Sp1 and p300 in scleroderma fibroblasts
[LiteratureReference:9737487] Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
COL1A2 gene expression is stimulated by p-2S-SMAD3:p-2S-SMAD3:SMAD4
output
[EntityWithAccessionedSequence:R-HSA-1980213] COL1A2(23-1366) [endoplasmic reticulum lumen]
precedingEvent
[Reaction:R-HSA-9733207] p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter - Homo sapiens
[Reaction:R-HSA-9733247] YBX1 binds COL1A2 gene promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:9733214] Positive gene expression regulation by 'p-2S-SMAD3:p-2S-SMAD3:SMAD4:SP1:EP300:COL1A2 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9736833] Negative gene expression regulation by 'p-2S-SMAD3:p-2S-SMAD3:SMAD4:p-S-YBX1:COL1A2 gene [nucleoplasm]'
releaseDate
2022年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9773670] Contreras, Osvaldo, 2022年05月02日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9733216
summation
[Summation:9737494] Binding of the heterotrimer composed of SMAD4 and two molecu...
Referrals
(precedingEvent)
[Reaction:R-HSA-8944214] Association of procollagen type I
[Reaction:R-HSA-2002460] P4HB binds Collagen chains
[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
(hasEvent)
[Pathway:R-HSA-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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