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Schema
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Reaction
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Entries
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
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authored
[InstanceEdit:9697308] Orlic-Milacic, Marija, 2020年08月12日
[InstanceEdit:9697675] Senff-Ribeiro, Andrea, 2020年08月12日
catalystActivity
[CatalystActivity:9713656] methyltransferase cap1 activity of m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:9684675] double membrane vesicle viral factory outer membrane
created
[InstanceEdit:9694660] Cook, Justin, 2020年07月07日
crossReference
[DatabaseIdentifier:11944893] Mondo:0100096
dbId
9694499
disease
[Disease:9683912] COVID-19
displayName
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
edited
[InstanceEdit:9697657] Orlic-Milacic, Marija, 2020年08月18日
eventOf
[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-9694733] Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand) - Homo sapiens
input
[Complex:R-COV-9713651] m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
[SimpleEntity:R-ALL-9639461] S-adenosyl-L-methionine [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9696948] Structural basis of RNA cap modification by SARS-CoV-2
[LiteratureReference:9735235] Mn
2+
coordinates Cap-0-RNA to align substrates for efficient 2'-
O
-methyl transfer by SARS-CoV-2 nsp16
[LiteratureReference:9756258] 2'-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
[LiteratureReference:9765245] A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2'-O methylation of its first nucleotide
[LiteratureReference:9765247] Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
output
[DefinedSet:R-COV-9694259] m7G(5')pppAm-SARS-CoV-2 plus strand subgenomic mRNAs [cytosol]
[Complex:R-COV-9694302] RTC [double membrane vesicle viral factory outer membrane]
[SimpleEntity:R-ALL-9639443] S-adenosyl-L-homocysteine [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-9694476] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs - Homo sapiens
relatedSpecies
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2020年09月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9699044] Acencio, Marcio Luis, 2020年09月09日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9694499
summation
[Summation:9694449] The function of the non-structural protein nsp16 as a 2'O-me...
updateTrackers
[UpdateTracker:9775723] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v78:[addLiteratureReference]
[UpdateTracker:9776338] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v76:[addOutput, add_removeCatalystActivity, add_removeInput]
[UpdateTracker:9775267] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v80:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9775723] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v78:[addLiteratureReference]
[UpdateTracker:9776338] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v76:[addOutput, add_removeCatalystActivity, add_removeInput]
[UpdateTracker:9775267] Update Tracker - [Reaction:9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs - v80:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs
(precedingEvent)
[BlackBoxEvent:R-HSA-9694733] Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)
[NegativePrecedingEvent:9763934] Futile Cycle: nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
[NegativePrecedingEvent:9763931] Futile Cycle: nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
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