Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Disease
>
Entries
COVID-19
Show undefined attributes
created
[InstanceEdit:9683909] Stephan, Ralf, 2020年04月17日
databaseName
DOID
dbId
9683912
definition
A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.
displayName
COVID-19
identifier
0080600
modified
[InstanceEdit:9683922] Stephan, Ralf, 2020年04月17日
name
COVID-19
referenceDatabase
[ReferenceDatabase:1247631] DOID
schemaClass
Disease
synonym
2019 Novel Coronavirus (2019-nCoV)
Wuhan seafood market pneumonia virus infection
2019-nCoV infection
Wuhan coronavirus infection
url
https://www.ebi.ac.uk/ols/ontologies/doid/terms?obo_id=DOID:0080600
Referrals
(disease)
[Pathway:R-HSA-9694516] SARS-CoV-2 Infection
[Pathway:R-HSA-9772573] Late SARS-CoV-2 Infection Events
[Pathway:R-HSA-9772572] Early SARS-CoV-2 Infection Events
[Pathway:R-HSA-9694682] SARS-CoV-2 Genome Replication and Transcription
[Pathway:R-HSA-9694686] Replication of the SARS-CoV-2 genome
[Reaction:R-HSA-9694541] SARS-CoV-2 gRNA:RTC:RNA primer binds RTC inhibitors
[BlackBoxEvent:R-HSA-9694792] nsp12 misincorporates a nucleotide in nascent RNA minus strand
[Reaction:R-HSA-9694665] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors
[Reaction:R-HSA-9694406] nsp13 binds DDX5
[Reaction:R-HSA-9694520] nsp16 binds VHL
[Reaction:R-HSA-9694677] ZCRB1 binds 5'UTR of SARS-CoV-2 genomic RNA
[Complex:R-HSA-9698376] ZCRB1:m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[Reaction:R-HSA-9694390] nsp15 binds RB1
[BlackBoxEvent:R-HSA-9755252] nsp15 cleaves viral poly(U)-RNA
[Complex:R-COV-9694359] SARS coronavirus gRNA with secondary structure:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9694419] SARS-CoV-2 gRNA complement (minus strand):RTC binds RTC inhibitors
[Pathway:R-HSA-9694786] Transcription of SARS-CoV-2 sgRNAs
[Pathway:R-HSA-9694676] Translation of Replicase and Assembly of the Replication Transcription Complex
[Pathway:R-HSA-9694301] Maturation of replicase proteins
[BlackBoxEvent:R-HSA-9731274] nsp16 localizes to the nucleus
[BlackBoxEvent:R-HSA-9694592] 3CLp dimer binds 3CLp inhibitors
[BlackBoxEvent:R-HSA-9731262] nsp6 localizes to the nuclear envelope
[DefinedSet:R-COV-9731255] nsp6 [nuclear envelope]
[EntityWithAccessionedSequence:R-COV-9731277] pp1ab-nsp6 [nuclear envelope]
[EntityWithAccessionedSequence:R-COV-9731276] pp1a-nsp6 [nuclear envelope]
[BlackBoxEvent:R-HSA-9694261] nsp9 forms a homotetramer
[Reaction:R-HSA-9732822] nsp3 binds to PLpro inhibitors
[Complex:R-COV-9733017] nsp3:PLpro inhibitors [cytosol]
[Pathway:R-HSA-9694271] Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)
[Reaction:R-HSA-9731708] nsp10:nsp14 binds to ExoN inhibitors
[Complex:R-COV-9815359] ExoN inhibitors:nsp10:nsp14 [cytosol]
[DefinedSet:R-ALL-9731679] ExoN inhibitors [cytosol]
[BlackBoxEvent:R-HSA-9698265] Enhanced autophagosome formation
[BlackBoxEvent:R-HSA-9694580] nsp8 binds MAP1LC3B
[Pathway:R-HSA-9694614] Attachment and Entry
[Reaction:R-HSA-9707827] Spike binds Spike inhibitors
[Pathway:R-HSA-9694635] Translation of Structural Proteins
[Pathway:R-HSA-9694493] Maturation of protein E
[BlackBoxEvent:R-HSA-9694790] E protein gets N-glycosylated
[Pathway:R-HSA-9694719] Maturation of protein 3a
[BlackBoxEvent:R-HSA-9694727] Endocytosis of protein 3a
[Pathway:R-HSA-9694548] Maturation of spike protein
[Pathway:R-HSA-9694631] Maturation of nucleoprotein
[BlackBoxEvent:R-HSA-9694575] Nucleoprotein translocates to the plasma membrane
[BlackBoxEvent:R-HSA-9694345] Nucleoprotein translocates to the nucleolus
[BlackBoxEvent:R-HSA-9694373] Unphosphorylated nucleoprotein translocates to the plasma membrane
[Pathway:R-HSA-9694594] Maturation of protein M
[Pathway:R-HSA-9733458] Induction of Cell-Cell Fusion
[Reaction:R-HSA-9770187] S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion
[EntityWithAccessionedSequence:R-COV-9770188] S(686-815) [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9770189] Spike S2' Fragment [plasma membrane]
[BlackBoxEvent:R-HSA-9770063] S1,S2 Dissociate from S1:ACE2:S2
[Complex:R-HSA-9770062] S1:ACE2 [plasma membrane]
[Reaction:R-HSA-9769949] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage
[Complex:R-HSA-9733494] S1 trimer:ACE2:S2 trimer [plasma membrane]
[Complex:R-COV-9796421] S1:S2 trimer [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9769950] S1 [plasma membrane]
[Reaction:R-HSA-9733495] Viral Spike Binds to ACE2 on Uninfected Cell
[Complex:R-HSA-9770060] Spike trimer:ACE2 [plasma membrane]
[BlackBoxEvent:R-HSA-9769812] Spike Trimer Translocates to the Plasma Membrane
[Complex:R-COV-9733504] Spike trimer [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9733472] fully glycosylated Spike [plasma membrane]
[Pathway:R-HSA-9727281] Translation of Accessory Proteins
[Reaction:R-HSA-9758486] Unknown kinase phosphorylates 9b
[Complex:R-HSA-9694566] nsp8:MAP1LC3B [cytosol]
[Complex:R-HSA-9694692] nsp13:DDX5 [cytosol]
[Complex:R-HSA-9694398] nsp16:VHL [cytosol]
[Complex:R-HSA-9694258] nsp15:RB1 [cytosol]
[Complex:R-COV-9694464] N dimer [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9729325] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
[Complex:R-COV-9694659] N dimer [nucleolus]
[EntityWithAccessionedSequence:R-COV-9729339] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
[EntityWithAccessionedSequence:R-COV-9694356] N [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9694754] N-glycan E [endoplasmic reticulum lumen]
[Pathway:R-HSA-9694322] Virion Assembly and Release
[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions
[ChemicalDrug:R-ALL-9835132] heparin [cytosol]
[DefinedSet:R-NUL-9684904] TLR7, TLR8 ligands [endosome lumen]
[DefinedSet:R-NUL-9684903] GU-rich ssRNA [endosome lumen]
[Pathway:R-HSA-9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction
[Reaction:R-HSA-9705681] MPP5 binds SARS-CoV-2 E pentamer
[Complex:R-HSA-9705682] MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9754644] SARS-CoV-2 E pentamer binds TJP1
[Complex:R-HSA-9754656] TJP1:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Pathway:R-HSA-9755779] SARS-CoV-2 targets host intracellular signalling and regulatory pathways
[Reaction:R-HSA-9729500] SARS-CoV-2 N binds to 14-3-3 proteins
[Complex:R-HSA-9729509] 14-3-3 dimer:N [cytosol]
[Reaction:R-HSA-9755777] SARS-CoV-2 M, N bind to PDPK1
[Reaction:R-HSA-9754518] SARS-CoV-2 3a tetramer binds to CAV1
[Complex:R-HSA-9754517] CAV1:3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9756470] N binds to heme
[Pathway:R-HSA-9754560] SARS-CoV-2 modulates autophagy
[BlackBoxEvent:R-HSA-9754554] SARS-COV 7a translocates to the late endosome membrane
[EntityWithAccessionedSequence:R-COV-9755945] 7a [endolysosome membrane]
[Reaction:R-HSA-9754537] SARS-CoV-2 3a tetramer binds to VPS39 within HOPS complex
[Complex:R-HSA-9754533] HOPS:3a [endolysosome membrane]
[Reaction:R-HSA-9730505] SARS-CoV-2 3a binds to UVRAG
[Complex:R-HSA-9730524] UVRAG:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[BlackBoxEvent:R-HSA-9754763] SARS-CoV-2 M protein binds TUFM
[BlackBoxEvent:R-HSA-9754775] SARS-CoV-2 M protein binds MAP1LC3B
[Complex:R-HSA-9755946] MAP1LC3B:TUFM:M [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-HSA-9754785] TUFM:M [endoplasmic reticulum membrane]
[Pathway:R-HSA-9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses
[Reaction:R-HSA-9757097] SARS-CoV-2 N binds NLRP3
[Complex:R-HSA-9757077] N:NLRP3 [cytosol]
[Reaction:R-HSA-9729704] SARS-CoV-2 3CLpro dimer cleaves TAB1
[Reaction:R-HSA-9729454] SARS-CoV-2 N protein binds STAT1, STAT2
[Reaction:R-HSA-9755757] SARS-CoV-2 N binds TAK1
[Reaction:R-HSA-9755747] SARS-CoV-2 N binds MAVS
[Complex:R-HSA-9755729] N:MAVS [cytosol]
[Reaction:R-HSA-9730528] SARS-CoV-2 3a binds to STING
[Complex:R-HSA-9730525] STING:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9705082] SARS-CoV-2 nsp13 binds TBK1
[Complex:R-HSA-9705087] TBK1:pp1ab-nsp13 [cytosol]
[Reaction:R-HSA-9755244] SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1
[DefinedSet:R-COV-9754749] SARS-CoV-2 dsRNA with poly(U)-containing (-) strand:RTC [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9754744] SARS-CoV-2 gRNA:RTC: 5'-poly(U) RNA minus strand [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9754741] SARS-CoV-2 nascent genomic 5'-poly(U)-RNA complement (minus strand) [cytosol]
[Complex:R-COV-9754740] SARS-CoV-2 5'-poly(U)-gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9754746] SARS-CoV-2 5'-poly(U)-gRNA complement (minus strand) [cytosol]
[Reaction:R-HSA-9754616] SARS-CoV-2 E pentamer transports Ca2+
[Reaction:R-HSA-9705010] SARS-CoV-2 nsp6 binds TBK1
[Complex:R-HSA-9705026] TBK1:pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]
[BlackBoxEvent:R-HSA-9754827] SARS-CoV-2 M binds TBK1
[Complex:R-HSA-9754834] M:TBK1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9729481] SARS-CoV-2 N binds to G3BP1,G3BP2
[Complex:R-HSA-9729513] G3BP1,G3BP2:N [cytosol]
[Reaction:R-HSA-9756494] CREBBP acetylates SARS-CoV-2 N at K375
[Complex:R-COV-9756485] SUMO1-K62,ADPr-,p-11S,2T,met-2R,Ac-K375-N dimer [cytosol]
[EntityWithAccessionedSequence:R-COV-9756489] SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
[GenomeEncodedEntity:R-COV-9754729] SARS-CoV-2 GU-rich ssRNA [endosome lumen]
[Reaction:R-HSA-9729741] SARS-CoV-2 3CLpro dimer cleaves NLRP12
[Reaction:R-HSA-9729725] SARS-CoV-2 nsp3 deISGylates ISGylated IRF3
[Reaction:R-HSA-9729730] SARS-CoV-2 nsp3 cleaves IRF3
[Reaction:R-HSA-9758529] SARS-CoV-2 N binds MASP2
[Complex:R-HSA-9758533] N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region]
[BlackBoxEvent:R-HSA-9716160] SARS-CoV-2 M protein binds MAVS
[Complex:R-HSA-9755714] M:MAVS [endoplasmic reticulum membrane]
[Complex:R-HSA-9729443] STAT1,STAT2:N [cytosol]
[Reaction:R-HSA-9730501] SARS-CoV-2 3CLpro dimer binds to STING
[Complex:R-HSA-9730518] STING:3CLpro dimer [cytosol]
[Reaction:R-HSA-9717658] SARS-CoV-2 N binds DDX58
[Complex:R-HSA-9717677] DDX58:N [cytosol]
[BlackBoxEvent:R-HSA-9727293] 6 localizes to the nuclear envelope
[EntityWithAccessionedSequence:R-COV-9727279] 6 [nuclear envelope]
[Reaction:R-HSA-9708889] SARS-CoV-2 6 binds NUP98:RAE1 within NPC
[Complex:R-HSA-9708891] 6:NPC [nuclear envelope]
[EntityWithAccessionedSequence:R-COV-9708916] 6 [cytosol]
[BlackBoxEvent:R-HSA-9694308] 3a is externalized together with membrane structures
[Complex:R-COV-9694475] 3a:membranous structure [extracellular region]
[Complex:R-COV-9694457] O-glycosyl 3a tetramer [extracellular region]
[EntityWithAccessionedSequence:R-COV-9694387] O-glycosyl 3a [extracellular region]
[BlackBoxEvent:R-HSA-9694572] 3a localizes to the cell membrane
[Reaction:R-HSA-9730521] SARS-CoV-2 3a induces potassium efflux
[Complex:R-COV-9694306] O-glycosyl 3a tetramer [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9694433] O-glycosyl 3a [plasma membrane]
[BlackBoxEvent:R-HSA-9727305] mRNA8 is translated to protein 8
[Reaction:R-HSA-9755354] 8 forms a homodimer
[Reaction:R-HSA-9755328] SARS-CoV-2 8 binds class I MHC
[Reaction:R-HSA-9755359] SARS-CoV-2 8:class I MHC binds BECN1
[Complex:R-HSA-9755322] 8:class I MHC:BECN1 complex [endoplasmic reticulum membrane]
[Complex:R-HSA-9755340] 8:antigen peptide bound class I MHC [lumenal side of endoplasmic reticulum membrane]
[Complex:R-COV-9755345] 8 homodimer [endoplasmic reticulum lumen]
[EntityWithAccessionedSequence:R-COV-9727283] 8 [endoplasmic reticulum lumen]
[Reaction:R-HSA-9709663] SARS-CoV-2 9b binds TOMM70
[EntityWithAccessionedSequence:R-COV-9758478] p-S53-9b [cytosol]
[Reaction:R-HSA-9756574] SARS-CoV-2 S binds SFTPD 12mer
[Complex:R-HSA-9756571] SFTPD:S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
[Reaction:R-HSA-9729437] SARS-CoV-2 N binds to TRIM25
[Complex:R-HSA-9729447] TRIM25:N [cytosol]
[DefinedSet:R-COV-9759710] SARS-CoV-2 G-rich RNA:RTC [double membrane vesicle viral factory outer membrane]
[Complex:R-HSA-9709659] TOMM70:9b [mitochondrial outer membrane]
[BlackBoxEvent:R-HSA-9727292] mRNA6 is translated to protein 6
[EntityWithAccessionedSequence:R-COV-9727295] 6 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9705299] SARS-CoV-2 6 binds KPNA2
[Complex:R-HSA-9705285] KPNA2:6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9705293] 6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[BlackBoxEvent:R-HSA-9727303] mRNA9 is translated to protein 9b
[BlackBoxEvent:R-HSA-9727284] 9b forms a homodimer
[BlackBoxEvent:R-HSA-9727300] 9b homodimer localizes to the mitochondrial outer membrane
[Complex:R-COV-9727285] 9b homodimer [cytosol]
[EntityWithAccessionedSequence:R-COV-9694649] 9b [cytosol]
[Reaction:R-HSA-9754839] SARS-CoV-2 9b binds IKBKG
[Complex:R-HSA-9754828] 9b:IKK complex [mitochondrial outer membrane]
[Complex:R-COV-9709655] 9b homodimer [mitochondrial outer membrane]
[EntityWithAccessionedSequence:R-COV-9709803] 9b [mitochondrial outer membrane]
[Reaction:R-HSA-9755734] SARS-CoV-2 N binds IKBKB
[Reaction:R-HSA-9755413] SARS-CoV-2 8 binds IL17RA
[Complex:R-HSA-9755355] 8:IL17RA [plasma membrane]
[Complex:R-COV-9755409] 8 homodimer [extracellular region]
[EntityWithAccessionedSequence:R-COV-9755410] 8 [extracellular region]
[Pathway:R-HSA-9754678] SARS-CoV-2 modulates host translation machinery
[Reaction:R-HSA-9729835] SARS-CoV-2 nsp9 binds to 7SL RNA
[Complex:R-HSA-9729785] 7SL RNA:nsp9 tetramer [cytosol]
[Complex:R-COV-9694286] nsp9 tetramer [cytosol]
[Complex:R-COV-9735243] nsp9 homodimer [cytosol]
[DefinedSet:R-COV-9694383] nsp9 [cytosol]
[Reaction:R-HSA-9729849] SARS-CoV-2 nsp1 binds to 40S ribosomal complex
[Complex:R-HSA-9729832] 40S ribosomal complex:nsp1 [cytosol]
[Reaction:R-HSA-9730488] SARS-CoV-2 nsp16 binds to U2 snRNA
[Complex:R-HSA-9730482] U2 snRNA:nsp16 [nucleoplasm]
[Reaction:R-HSA-9730483] SARS-CoV-2 nsp16 binds to U1 snRNA
[Complex:R-HSA-9730486] U1 snRNA:nsp16 [nucleoplasm]
[EntityWithAccessionedSequence:R-COV-9730487] pp1ab-nsp16 [nucleoplasm]
[Reaction:R-HSA-9699007] FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
[Reaction:R-HSA-9697423] Endocytosis of SARS-CoV-2 Virion
[Reaction:R-HSA-9694287] Cleavage of S protein into S1:S2
[BlackBoxEvent:R-HSA-9727297] mRNA7 is translated to protein 7a
[BlackBoxEvent:R-HSA-9727288] 7a localizes to the ERGIC membrane
[EntityWithAccessionedSequence:R-COV-9727308] 7a [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9694568] Nucleoprotein translocates to the ERGIC outer membrane
[Reaction:R-HSA-9694455] SUMO-p-N protein dimer binds genomic RNA
[Reaction:R-HSA-9694281] Encapsidation of SARS coronavirus genomic RNA
[BlackBoxEvent:R-HSA-9694280] mRNA4 is translated to protein E
[Reaction:R-HSA-9694401] E protein gets palmitoylated
[EntityWithAccessionedSequence:R-COV-9694312] nascent E [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9694529] Ubiquination of protein E
[EntityWithAccessionedSequence:R-COV-9694305] 3xPalmC-E [endoplasmic reticulum lumen]
[Reaction:R-HSA-9694452] Protein E forms a homopentamer
[EntityWithAccessionedSequence:R-COV-9694423] Ub-3xPalmC-E [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9694294] E pentamer is transported to the Golgi
[Complex:R-COV-9694787] Ub-3xPalmC-E pentamer [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694465] Ub-3xPalmC-E [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9694525] M protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9694367] Glycosylated M localizes to the Golgi membrane
[BlackBoxEvent:R-HSA-9694681] mRNA5 is translated to protein M
[BlackBoxEvent:R-HSA-9694555] Protein M localizes to the Golgi membrane
[Reaction:R-HSA-9694487] M protein oligomerization
[Reaction:R-HSA-9694444] E and N are recruited to the M lattice
[BlackBoxEvent:R-HSA-9694447] mRNA2 is translated to Spike
[BlackBoxEvent:R-HSA-9694793] Spike protein gets N-glycosylated
[EntityWithAccessionedSequence:R-COV-9694796] nascent Spike [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9694364] N-glycan glucose trimming of Spike
[EntityWithAccessionedSequence:R-COV-9694459] 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9696807] N-glycan mannose trimming of Spike
[EntityWithAccessionedSequence:R-COV-9696892] Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
[Reaction:R-HSA-9694337] Trimmed spike protein binds to calnexin
[EntityWithAccessionedSequence:R-COV-9696875] high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
[BlackBoxEvent:R-HSA-9694780] Spike translocates to ERGIC
[EntityWithAccessionedSequence:R-COV-9696880] high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
[Reaction:R-HSA-9694341] Spike protein gets palmitoylated
[EntityWithAccessionedSequence:R-COV-9766369] high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
[Reaction:R-HSA-9694467] Spike protein forms a homotrimer
[BlackBoxEvent:R-HSA-9694656] Spike trimer glycoside chains are extended
[Complex:R-COV-9696901] high-mannose N-glycan-PALM-Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]
[EntityWithAccessionedSequence:R-COV-9696943] high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
[BlackBoxEvent:R-HSA-9696980] Spike trimer glycoside chains get additional branches
[Complex:R-COV-9697195] di-antennary N-glycan-PALM-Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]
[EntityWithAccessionedSequence:R-COV-9696920] di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
[BlackBoxEvent:R-HSA-9697018] Addition of sialic acids on some Spike glycosyl sidechains
[Complex:R-COV-9697194] tri-antennary N-glycan-PALM-Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]
[EntityWithAccessionedSequence:R-COV-9697006] tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
[BlackBoxEvent:R-HSA-9698333] Spike trimer moves into the ERGIC membrane
[Complex:R-COV-9697197] fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment]
[EntityWithAccessionedSequence:R-COV-9696997] fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
[Reaction:R-HSA-9694553] Recruitment of Spike trimer to assembling virion
[Reaction:R-HSA-9694445] nsp16 binds nsp10
[Reaction:R-HSA-9694542] nsp14 binds nsp10
[Reaction:R-HSA-9765952] nsp12 guanylates nsp7
[DefinedSet:R-COV-9691334] nsp7 [cytosol]
[Reaction:R-HSA-9691335] nsp7 binds nsp8
[BlackBoxEvent:R-HSA-9771686] nsp12 acquires Fe-S cluster cofactors
[Reaction:R-HSA-9691363] nsp12 binds nsp7 and nsp8
[Reaction:R-HSA-9694304] nsp14 binds nsp12
[Reaction:R-HSA-9694524] nsp13 binds nsp12
[Reaction:R-HSA-9694436] nsp15 forms a hexamer
[Reaction:R-HSA-9694539] nsp15 binds nsp8
[Reaction:R-HSA-9694551] 3CLp cleaves nsp6-11
[EntityWithAccessionedSequence:R-COV-9681995] pp1a-nsp7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681990] pp1a-nsp11 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681991] pp1a-nsp9 [cytosol]
[BlackBoxEvent:R-HSA-9694331] nsp3-4 is glycosylated
[DefinedSet:R-COV-9694479] N-glycan nsp3-4 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694559] N-glycan pp1a-nsp3-4 [endoplasmic reticulum membrane]
[Reaction:R-HSA-9694333] 3CLp forms a homodimer
[Complex:R-COV-9694402] SUMO-p-N dimer:SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9694684] N-glycan M [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694279] nascent M [endoplasmic reticulum lumen]
[Complex:R-COV-9694408] Ub-3xPalmC-E pentamer [Golgi membrane]
[EntityWithAccessionedSequence:R-COV-9694687] Ub-3xPalmC-E [Golgi membrane]
[Complex:R-COV-9694491] M lattice:E protein:encapsidated SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694664] M lattice:E protein [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9767620] M [endoplasmic reticulum membrane]
[Complex:R-COV-9754528] O-glycosyl 3a tetramer [endolysosome membrane]
[EntityWithAccessionedSequence:R-COV-9754541] O-glycosyl 3a [endolysosome membrane]
[Complex:R-HSA-9694758] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen]
[EntityWithAccessionedSequence:R-COV-9769952] complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
[BlackBoxEvent:R-HSA-9694277] nsp8 generates RNA primers
[BlackBoxEvent:R-HSA-9694605] nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement
[Complex:R-COV-9694255] SARS-CoV-2 gRNA:RTC:RNA primer:RTC inhibitors [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694725] SARS-CoV-2 gRNA:RTC:RNA primer [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9694632] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
[Complex:R-COV-9694269] SARS coronavirus gRNA:RTC:nascent RNA minus strand with mismatched nucleotide [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694434] SARS-CoV-2 nascent genomic RNA complement (minus strand) with mismatched 3' nucleotide [cytosol]
[BlackBoxEvent:R-HSA-9694549] RTC completes synthesis of the minus strand genomic RNA complement
[Complex:R-COV-9694327] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand:RTC inhibitors [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694618] SARS-CoV-2 gRNA:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694488] SARS-CoV-2 nascent genomic RNA complement (minus strand) [cytosol]
[BlackBoxEvent:R-HSA-9694492] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
[Complex:R-COV-9713636] SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694708] SARS-CoV-2 genomic RNA complement (minus strand) [cytosol]
[Reaction:R-HSA-9694521] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)
[Complex:R-COV-9713634] m7GpppA-capped SARS-CoV-2 genomic RNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694278] m7GpppA-capped SARS-CoV-2 genomic RNA complement (minus strand) [cytosol]
[Reaction:R-HSA-9694495] RTC binds SARS-CoV-2 genomic RNA complement (minus strand)
[BlackBoxEvent:R-HSA-9694581] RTC synthesizes SARS-CoV-2 plus strand genomic RNA
[Complex:R-COV-9694690] SARS-CoV-2 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694404] SARS-CoV-2 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694603] m7G(5')pppAm-capped SARS-CoV-2 genomic RNA complement (minus strand) [cytosol]
[BlackBoxEvent:R-HSA-9694737] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
[Complex:R-COV-9713644] SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694339] SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[Reaction:R-HSA-9694721] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 gRNA (plus strand)
[Complex:R-COV-9713643] m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694712] m7GpppA-capped SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[BlackBoxEvent:R-HSA-9694471] Polyadenylation of SARS-CoV-2 genomic RNA (plus strand)
[EntityWithAccessionedSequence:R-COV-9694619] m7G(5')pppAm-capped SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[BlackBoxEvent:R-HSA-9694274] mRNA1 is translated to pp1ab
[Reaction:R-HSA-9694732] 3CLp cleaves pp1ab
[EntityWithAccessionedSequence:R-COV-9682061] pp1ab-nsp7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694697] pp1ab-nsp9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9682068] pp1ab [cytosol]
[BlackBoxEvent:R-HSA-9694567] pp1a forms a dimer
[Reaction:R-HSA-9694377] pp1a cleaves itself
[Complex:R-COV-9694743] pp1a dimer [cytosol]
[Reaction:R-HSA-9694338] nsp1-4 cleaves itself
[Reaction:R-HSA-9694601] nsp3-4 cleaves itself
[DefinedSet:R-COV-9694554] nsp3-4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694468] pp1a-nsp3-4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694533] pp1ab-nsp3-4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694600] N-glycan pp1ab-nsp3-4 [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9694389] nsp3 is glycosylated
[Reaction:R-HSA-9694625] nsp3 cleaves nsp1-4
[DefinedSet:R-COV-9694428] nsp3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694766] pp1ab-nsp3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681993] pp1a-nsp3 [cytosol]
[DefinedSet:R-COV-9694760] nsp2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681988] pp1a-nsp2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694515] pp1ab-nsp2 [cytosol]
[DefinedSet:R-COV-9694741] nsp1 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694412] pp1ab-nsp1 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681989] pp1a-nsp1 [cytosol]
[DefinedSet:R-COV-9694784] nsp1-4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694695] pp1ab-nsp1-4 [cytosol]
[BlackBoxEvent:R-HSA-9694611] nsp4 is glycosylated
[DefinedSet:R-COV-9694577] nsp4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681984] pp1a-nsp4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694497] pp1ab-nsp4 [cytosol]
[BlackBoxEvent:R-HSA-9694317] Nsp3, nsp4, and nsp6 produce replicative organelles
[DefinedSet:R-COV-9694735] N-glycan nsp3 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694746] N-glycan pp1ab-nsp3 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694315] N-glycan pp1a-nsp3 [endoplasmic reticulum membrane]
[DefinedSet:R-COV-9694361] nsp6 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694425] pp1ab-nsp6 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694256] pp1a-nsp6 [endoplasmic reticulum membrane]
[DefinedSet:R-COV-9694569] N-glycan nsp4 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694652] N-glycan pp1ab-nsp4 [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-COV-9694763] N-glycan pp1a-nsp4 [endoplasmic reticulum membrane]
[BlackBoxEvent:R-HSA-9694630] Nsp3:nsp4 binds to nsp6
[BlackBoxEvent:R-HSA-9694576] nsp3 binds to nsp7-8 and nsp12-16
[Reaction:R-HSA-9694454] Replication transcription complex binds SARS-CoV-2 genomic RNA
[BlackBoxEvent:R-HSA-9694265] nsp13 helicase melts secondary structures in SARS-CoV-2 genomic RNA template
[Complex:R-COV-9694731] SARS coronavirus 2 gRNA with secondary structure:RTC [double membrane vesicle viral factory outer membrane]
[BlackBoxEvent:R-HSA-9694370] mRNA9a is translated to Nucleoprotein
[Reaction:R-HSA-9729330] SRPK1/2 phosphorylates nucleoprotein
[EntityWithAccessionedSequence:R-COV-9694300] N [cytosol]
[Reaction:R-HSA-9729260] GSK3 phosphorylates nucleoprotein
[EntityWithAccessionedSequence:R-COV-9729324] p-S188,206-N [cytosol]
[Reaction:R-HSA-9729318] CSNK1A1 phosphorylates nucleoprotein
[EntityWithAccessionedSequence:R-COV-9729335] p-8S-N [cytosol]
[Reaction:R-HSA-9729300] Unknown kinase phosphorylates nucleoprotein
[EntityWithAccessionedSequence:R-COV-9729277] p-8S,2T-N [cytosol]
[Reaction:R-HSA-9729283] Nucleoprotein is methylated by PRMT1
[ChemicalDrug:R-ALL-9766614] MS023 [cytosol]
[EntityWithAccessionedSequence:R-COV-9729264] p-11S,2T-N [cytosol]
[Reaction:R-HSA-9729279] Nucleoprotein is ADP-ribosylated
[EntityWithAccessionedSequence:R-COV-9729308] p-11S,2T-metR95,177-N [cytosol]
[Reaction:R-HSA-9729307] Nucleoprotein is SUMOylated
[EntityWithAccessionedSequence:R-COV-9729275] ADPr-p-11S,2T-metR95,177-N [cytosol]
[Reaction:R-HSA-9694363] Dimerisation of nucleoprotein
[BlackBoxEvent:R-HSA-9694344] Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching
[Complex:R-COV-9694458] SARS-CoV-2 gRNA:RTC [double membrane vesicle viral factory outer membrane]
[BlackBoxEvent:R-HSA-9694506] Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs
[Complex:R-COV-9713652] SARS-CoV-2 minus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9694501] SARS-CoV-2 minus strand subgenomic mRNAs [cytosol]
[EntityWithAccessionedSequence:R-COV-9694588] mRNA8 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694621] mRNA5 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694511] mRNA6 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9697259] mRNA7b minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694347] mRNA2 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694629] mRNA7a minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694550] mRNA9 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694753] mRNA3 minus strand [cytosol]
[EntityWithAccessionedSequence:R-COV-9694755] mRNA4 minus strand [cytosol]
[Reaction:R-HSA-9815529] nsp12 transfers guanylyl onto SARS-CoV-2 plus strand subgenomic RNAs
[BlackBoxEvent:R-HSA-9694476] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs
[Complex:R-COV-9792635] GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9792631] GpppA-SARS-CoV-2 plus strand subgenomic mRNAs [cytosol]
[EntityWithAccessionedSequence:R-COV-9792632] GpppAm-mRNA2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792633] GpppAm-mRNA7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792622] GpppAm-mRNA8 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792638] GpppAm-mRNA6 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792637] GpppAm-mRNA3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792624] GpppAm-mRNA9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792630] GpppAm-mRNA4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9792628] GpppAm-mRNA5 [cytosol]
[Complex:R-COV-9713653] SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9694701] SARS-CoV-2 plus strand subgenomic mRNAs [cytosol]
[EntityWithAccessionedSequence:R-COV-9694460] mRNA2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694382] mRNA9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694264] mRNA4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694410] mRNA7a [cytosol]
[EntityWithAccessionedSequence:R-COV-9694490] mRNA6 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694260] mRNA8 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694582] mRNA3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694546] mRNA5 [cytosol]
[EntityWithAccessionedSequence:R-COV-9697251] mRNA7b [cytosol]
[Reaction:R-HSA-9694499] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-2 mRNAs
[Complex:R-COV-9713651] m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs:RTC [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694302] RTC [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694728] nsp3:nsp4:nsp6 [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694366] nsp3:nsp4 [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9694470] nsp3 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694430] pp1ab-nsp3 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694720] pp1a-nsp3 [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9694481] nsp4 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694607] pp1ab-nsp4 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694767] pp1a-nsp4 [double membrane vesicle viral factory outer membrane]
[DefinedSet:R-COV-9694770] nsp6 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694777] pp1ab-nsp6 [double membrane vesicle viral factory outer membrane]
[EntityWithAccessionedSequence:R-COV-9694615] pp1a-nsp6 [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9694740] nsp7:nsp8:nsp12:nsp14:nsp10:nsp13:nsp15 [cytosol]
[Complex:R-COV-9694717] nsp7:nsp8:nsp12:nsp14:nsp10:nsp13 [cytosol]
[Complex:R-COV-9694597] nsp7:nsp8:nsp12:nsp14:nsp10 [cytosol]
[Complex:R-COV-9691364] nsp7:nsp8:nsp12 [cytosol]
[Complex:R-COV-9771682] nsp12:2Fe4S4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9682057] pp1ab-nsp12 [cytosol]
[Complex:R-COV-9691348] nsp7:nsp8 [cytosol]
[DefinedSet:R-COV-9765944] N6GMPLys-nsp7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9765953] N6GMPLys-pp1a-nsp7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9765943] N6GMPLys-pp1ab-nsp7 [cytosol]
[Complex:R-COV-9694688] nsp10:nsp14 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694537] pp1ab-nsp14 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694642] pp1ab-nsp13 [cytosol]
[Complex:R-COV-9694570] nsp15 hexamer [cytosol]
[EntityWithAccessionedSequence:R-COV-9694335] pp1ab-nsp15 [cytosol]
[Complex:R-COV-9694416] nsp16:nsp10 [cytosol]
[DefinedSet:R-COV-9694358] nsp10 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681983] pp1a-nsp10 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694372] pp1ab-nsp10 [cytosol]
[DefinedSet:R-COV-9694711] m7GpppA-SARS-CoV-2 plus strand subgenomic mRNAs [cytosol]
[EntityWithAccessionedSequence:R-COV-9694703] m7GpppA-mRNA4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694587] m7GpppA-mRNA5 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694292] m7GpppA-mRNA6 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694484] m7GpppA-mRNA2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694663] m7GpppA-mRNA9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694384] m7GpppA-mRNA7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694771] m7GpppA-mRNA8 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694675] m7GpppA-mRNA3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694647] pp1ab-nsp16 [cytosol]
[BlackBoxEvent:R-HSA-9694733] Polyadenylation of SARS-CoV-2 subgenomic mRNAs (plus strand)
[DefinedSet:R-COV-9694561] m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 subgenomic mRNAs (plus strand) [cytosol]
[EntityWithAccessionedSequence:R-COV-9694285] m7G(5')pppAm-capped,polyadenylated mRNA6 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694622] m7G(5')pppAm-capped,polyadenylated mRNA4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694456] m7G(5')pppAm-capped,polyadenylated mRNA5 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694503] m7G(5')pppAm-capped,polyadenylated mRNA2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694496] m7G(5')pppAm-capped,polyadenylated mRNA7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694513] m7G(5')pppAm-capped,polyadenylated-mRNA9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694354] m7G(5')pppAm-capped,polyadenylated mRNA8 [cytosol]
[DefinedSet:R-COV-9694259] m7G(5')pppAm-SARS-CoV-2 plus strand subgenomic mRNAs [cytosol]
[EntityWithAccessionedSequence:R-COV-9694350] m7G(5')pppAm-mRNA8 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694266] m7G(5')pppAm-mRNA3 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694523] m7G(5')pppAm-mRNA9 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694699] m7G(5')pppAm-mRNA4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694757] m7G(5')pppAm-mRNA6 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694613] m7G(5')pppAm-mRNA2 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694710] m7G(5')pppAm-mRNA7 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694352] m7G(5')pppAm-mRNA5 [cytosol]
[BlackBoxEvent:R-HSA-9694794] mRNA3 is translated to protein 3a
[EntityWithAccessionedSequence:R-COV-9694325] m7G(5')pppAm-capped,polyadenylated mRNA3 [cytosol]
[BlackBoxEvent:R-HSA-9694392] 3a translocates to the ERGIC
[EntityWithAccessionedSequence:R-COV-9694584] 3a [endoplasmic reticulum lumen]
[Reaction:R-HSA-9694438] GalNAc is transferred onto 3a
[EntityWithAccessionedSequence:R-COV-9694716] 3a [endoplasmic reticulum-Golgi intermediate compartment]
[Reaction:R-HSA-9694718] O-glycosylation of 3a is terminated
[EntityWithAccessionedSequence:R-COV-9694658] GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]
[Reaction:R-HSA-9694662] Protein 3a forms a homotetramer
[Reaction:R-HSA-9694528] Accessory proteins are recruited to the maturing virion
[Complex:R-COV-9694321] S3:M:E:encapsidated SARS-CoV-2 genomic RNA:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9694633] SARS virus buds into ERGIC lumen
[Complex:R-COV-9694324] S3:M:E:encapsidated SARS-CoV-2 genomic RNA:7a:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694590] 7a:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9694750] 7a [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694598] O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9694386] O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694612] encapsidated SARS-CoV-2 genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694573] N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694502] S3:M lattice:E protein [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9698334] fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9698330] fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9698418] Ub-3xPalmC-E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9698420] Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9694371] M lattice [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9694446] N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
[EntityWithAccessionedSequence:R-COV-9694439] M [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9694641] Viral release
[Complex:R-COV-9752958] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [exocytic vesicle]
[BlackBoxEvent:R-HSA-9698988] Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid
[Complex:R-COV-9698997] S1:S2:M lattice:E protein [plasma membrane]
[Complex:R-COV-9698989] Ub-3xPalmC-E pentamer [plasma membrane]
[Complex:R-COV-9698986] complex N-glycan-PALM-Spike S1 fragment trimer [plasma membrane]
[Complex:R-COV-9698996] M lattice [plasma membrane]
[Complex:R-COV-9698995] S2 trimer [plasma membrane]
[Reaction:R-HSA-9694579] Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell
[ProteinDrug:R-ALL-9733131] etesevimab [extracellular region]
[ProteinDrug:R-ALL-9733136] bamlanivimab [extracellular region]
[ChemicalDrug:R-ALL-9767462] heparin [extracellular region]
[Reaction:R-HSA-9694661] TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis
[Complex:R-HSA-9694785] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region]
[Reaction:R-HSA-9694689] Fusion and Release of SARS-CoV-2 Nucleocapsid
[Complex:R-COV-9694534] S1:S2:M:E: 7a:O-glycosyl 3a tetramer [endocytic vesicle membrane]
[Complex:R-COV-9694776] 7a:O-glycosyl 3a tetramer [endocytic vesicle membrane]
[Complex:R-COV-9694781] O-glycosyl 3a tetramer [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694729] O-glycosyl 3a [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694645] 7a [endocytic vesicle membrane]
[Complex:R-COV-9694474] S1:S2:M lattice:E protein [endocytic vesicle membrane]
[Complex:R-COV-9694606] complex N-glycan-PALM-Spike S1 fragment trimer [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694745] complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
[Complex:R-COV-9694552] M lattice [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694738] N-glycan M [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694563] M [endocytic vesicle membrane]
[Complex:R-COV-9694756] complex N-glycan-PALM-Spike S2 fragment trimer [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9694343] complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
[Complex:R-COV-9698421] Ub-3xPalmC-E pentamer [endocytic vesicle membrane]
[EntityWithAccessionedSequence:R-COV-9698422] Ub-3xPalmC-E [endocytic vesicle membrane]
[Complex:R-COV-9694585] S1:S2:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]
[Complex:R-COV-9694783] S1:S2:M lattice:E protein [virion membrane]
[Complex:R-COV-9694413] complex N-glycan-PALM-Spike S2 fragment trimer [virion membrane]
[EntityWithAccessionedSequence:R-COV-9694791] complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
[Complex:R-COV-9694421] complex N-glycan-PALM-Spike S1 fragment trimer [virion membrane]
[EntityWithAccessionedSequence:R-COV-9755780] M [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9729340] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
[Complex:R-COV-9694702] N dimer [cytosol]
[Complex:R-HSA-9755778] N:M:PDPK1 [plasma membrane]
[EntityWithAccessionedSequence:R-COV-9697431] m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [viral capsid]
[EntityWithAccessionedSequence:R-COV-9729341] SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9697429] N dimer [viral capsid]
[Complex:R-COV-9697428] encapsidated SARS-CoV-2 genomic RNA [viral capsid]
[EntityWithAccessionedSequence:R-COV-9694648] 7a [virion membrane]
[EntityWithAccessionedSequence:R-COV-9694395] O-glycosyl 3a [virion membrane]
[Complex:R-COV-9694268] O-glycosyl 3a tetramer [virion membrane]
[Complex:R-COV-9694427] 7a:O-glycosyl 3a tetramer [virion membrane]
[EntityWithAccessionedSequence:R-COV-9698327] fully glycosylated Spike [virion membrane]
[Complex:R-COV-9698338] fully glycosylated Spike trimer [virion membrane]
[EntityWithAccessionedSequence:R-COV-9698416] Ub-3xPalmC-E [virion membrane]
[Complex:R-COV-9698417] Ub-3xPalmC-E pentamer [virion membrane]
[EntityWithAccessionedSequence:R-COV-9694385] N-glycan M [virion membrane]
[EntityWithAccessionedSequence:R-COV-9694320] M [virion membrane]
[Complex:R-COV-9694698] M lattice [virion membrane]
[Complex:R-COV-9694714] S3:M lattice:E protein [virion membrane]
[Complex:R-COV-9694500] S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
[Complex:R-HSA-9755745] N:TAK1complex [cytosol]
[Complex:R-HSA-9755930] N:CHUK:IKBKB:IKBKG [cytosol]
[EntityWithAccessionedSequence:R-COV-9682052] pp1ab-nsp8 [cytosol]
[EntityWithAccessionedSequence:R-COV-9681992] pp1a-nsp8 [cytosol]
[DefinedSet:R-COV-9691351] nsp8 [cytosol]
[Complex:R-HSA-9729808] 7SL RNA:nsp8 [cytosol]
[Reaction:R-HSA-9729841] SARS-CoV-2 nsp8 binds to 7SL RNA
[EntityWithAccessionedSequence:R-COV-9681994] pp1a-3CL [cytosol]
[EntityWithAccessionedSequence:R-COV-9694504] pp1ab-nsp5 [cytosol]
[DefinedSet:R-COV-9694748] nsp5 [cytosol]
[Complex:R-COV-9694407] 3CLp dimer [cytosol]
[EntityWithAccessionedSequence:R-COV-9681986] pp1a [cytosol]
[EntityWithAccessionedSequence:R-COV-9694778] pp1a-nsp1-4 [cytosol]
[EntityWithAccessionedSequence:R-COV-9694668] pp1a-nsp6-11 [cytosol]
[ChemicalDrug:R-ALL-9731197] PF-00835231 [cytosol]
[ChemicalDrug:R-ALL-9731198] nirmatrelvir [cytosol]
[ChemicalDrug:R-ALL-9731712] ebselen [cytosol]
[ChemicalDrug:R-ALL-9731691] boceprevir [cytosol]
[DefinedSet:R-ALL-9731705] 3CLp inhibitors [cytosol]
[Complex:R-COV-9694375] 3CLp dimer:3CLp inhibitors [cytosol]
[Reaction:R-HSA-9694441] 3CLp cleaves pp1a
[EntityWithAccessionedSequence:R-COV-9694393] m7G(5')pppAm-capped, polyadenylated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[BlackBoxEvent:R-HSA-9694334] mRNA1 is translated to pp1a
[Complex:R-COV-9694461] encapsidated SARS-CoV-2 genomic RNA (plus strand) [cytosol]
[Reaction:R-HSA-9694723] Uncoating of SARS-CoV-2 Genome
[EntityWithAccessionedSequence:R-COV-9694638] complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル