Reactome Pathway Database

Schema > Complex > Entries

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] Show undefined attributes

compartment

[Compartment:74700] endosome membrane

componentOf

[Complex:R-HSA-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] - Homo sapiens

consumedByEvent

[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Homo sapiens

created [InstanceEdit:937009] Shamovsky, V, 2010年08月25日

dbId 937016

displayName K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

hasComponent

inDisease false

includedLocation

inferredTo

literatureReference

maxDepth 6

modified [InstanceEdit:9014318] Shamovsky, Veronica, 2017年07月28日

name

K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14
activated TLR4:TRIF:K63pUb-RIP1

negativelyRegulates

[NegativeRegulation:R-HSA-2569044] Negative regulation by 'K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'

producedByEvent

[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens

schemaClass Complex

species

[Species:48887] Homo sapiens

stId R-HSA-937016

updateTrackers

Referrals

(updatedInstance)

(hasComponent)

[Complex:R-HSA-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]

(input)

[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1

(output)

[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex

(regulator)

[NegativeRegulation:R-HSA-2569044] Negative regulation by 'K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]'

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