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Schema
>
Reaction
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Entries
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
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authored
[InstanceEdit:166017] de Bono, B, 2005年08月16日 10:54:15
catalystActivity
[CatalystActivity:2569080] ubiquitin-protein transferase activity of RIP1 ubiqutin ligases [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
created
[InstanceEdit:168919] de Bono, B, 2005年11月22日 18:36:47
dbId
168915
displayName
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
edited
[InstanceEdit:1485578] Shamovsky, V, 2011年08月12日
eventOf
[Pathway:R-HSA-937041] IKK complex recruitment mediated by RIP1 - Homo sapiens
followingEvent
[Reaction:R-HSA-9014343] IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex - Homo sapiens
[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Homo sapiens
input
2 ×
[Polymer:R-HSA-450152] K63polyUb [cytosol]
[Complex:R-HSA-168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:451562] Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
[LiteratureReference:2569072] cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
orthologousEvent
[Reaction:R-GGA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Gallus gallus
[Reaction:R-SSC-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Sus scrofa
[Reaction:R-BTA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Bos taurus
[Reaction:R-CFA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Canis familiaris
[Reaction:R-RNO-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Rattus norvegicus
[Reaction:R-MMU-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Mus musculus
output
[Complex:R-HSA-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent
[Reaction:R-HSA-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Homo sapiens
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006年04月24日 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010年11月30日
[InstanceEdit:2582977] Fitzgerald, Katherine A, 2012年11月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-168915
summation
[Summation:939839] RIP1 polyubiquitination was induced upon TNF- or poly(I-C) t...
updateTrackers
[UpdateTracker:9788158] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v43:[addCatalystActivity, addLiteratureReference]
[UpdateTracker:9791864] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v25:[add_removeOutput]
[UpdateTracker:9780629] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v62:[removeLiteratureReference]
Referrals
(updatedInstance)
[UpdateTracker:9788158] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v43:[addCatalystActivity, addLiteratureReference]
[UpdateTracker:9791864] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v25:[add_removeOutput]
[UpdateTracker:9780629] Update Tracker - [Reaction:168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - v62:[removeLiteratureReference]
(precedingEvent)
[Reaction:R-HSA-9014343] IKBKG subunit of IKK complex binds K63pUb- RIP1 within the TLR3 complex
[Reaction:R-HSA-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1
(hasEvent)
[Pathway:R-HSA-937041] IKK complex recruitment mediated by RIP1
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