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Schema
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Reaction
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Entries
ME3 tetramer decarboxylates MAL to PYR
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authored
[InstanceEdit:9012352] Jassal, Bijay, 2017年07月13日
catalystActivity
[CatalystActivity:9012354] malate dehydrogenase (decarboxylating) (NADP+) activity of ME3:Mg2+ tetramer [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
created
[InstanceEdit:9012352] Jassal, Bijay, 2017年07月13日
crossReference
[DatabaseIdentifier:12610613] Rhea:18254
[DatabaseIdentifier:9861894] RHEA:18254
dbId
9012349
displayName
ME3 tetramer decarboxylates MAL to PYR
edited
[InstanceEdit:9012352] Jassal, Bijay, 2017年07月13日
eventOf
[Pathway:R-HSA-70268] Pyruvate metabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT - Homo sapiens
[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
[Reaction:R-HSA-9861745] Mitochondrial H2O2 decarboxylates PYR to acetate - Homo sapiens
[Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT - Homo sapiens
input
[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
[SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9012351] Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme
[LiteratureReference:9012020] Structure and function of malic enzymes, a new class of oxidative decarboxylases
[LiteratureReference:9012367] Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic ?-cells
[LiteratureReference:9012021] Biophysical characterization of the dimer and tetramer interface interactions of the human cytosolic malic enzyme
[LiteratureReference:9861863] Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer
[LiteratureReference:9861837] The Pancreatic ?-Cell: The Perfect Redox System
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
ME3 tetramer decarboxylates MAL to PYR
ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR
orthologousEvent
[Reaction:R-CFA-9012349] ME3 tetramer decarboxylates MAL to PYR - Canis familiaris
[Reaction:R-DME-9012349] ME3 tetramer decarboxylates MAL to PYR - Drosophila melanogaster
[Reaction:R-GGA-9012349] ME3 tetramer decarboxylates MAL to PYR - Gallus gallus
[Reaction:R-CEL-9012349] ME3 tetramer decarboxylates MAL to PYR - Caenorhabditis elegans
[Reaction:R-XTR-9012349] ME3 tetramer decarboxylates MAL to PYR - Xenopus tropicalis
[Reaction:R-DRE-9012349] ME3 tetramer decarboxylates MAL to PYR - Danio rerio
[Reaction:R-SSC-9012349] ME3 tetramer decarboxylates MAL to PYR - Sus scrofa
[Reaction:R-BTA-9012349] ME3 tetramer decarboxylates MAL to PYR - Bos taurus
[Reaction:R-RNO-9012349] ME3 tetramer decarboxylates MAL to PYR - Rattus norvegicus
[Reaction:R-MMU-9012349] ME3 tetramer decarboxylates MAL to PYR - Mus musculus
output
[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix]
[SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
[SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2018年03月21日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9036107] Hung, Hui-Chih, 2018年01月30日
[InstanceEdit:9862191] Hill, David P, 2024年02月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9012349
summation
[Summation:9012357] NADP-dependent malic enzyme (ME3, aka m-NADP-ME) is a mitoch...
updateTrackers
[UpdateTracker:9864358] Update Tracker - [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR - v88:[addLiteratureReference, modifyText, removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9864358] Update Tracker - [Reaction:9012349] ME3 tetramer decarboxylates MAL to PYR - v88:[addLiteratureReference, modifyText, removeOutput]
(hasEvent)
[Pathway:R-HSA-70268] Pyruvate metabolism
(precedingEvent)
[Reaction:R-HSA-9861745] Mitochondrial H2O2 decarboxylates PYR to acetate
[Reaction:R-HSA-9861734] PDH E1 decarboxylates PYR, transferring acetyl to DLAT
[Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT
[Reaction:R-HSA-70501] PC carboxylates PYR to OA
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