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Schema
>
Pathway
>
Entries
Pyruvate metabolism
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compartment
[Compartment:70101] cytosol
[Compartment:17927] mitochondrial intermembrane space
[Compartment:5460] mitochondrial matrix
dbId
70268
displayName
Pyruvate metabolism
doi
10.3180/R-HSA-70268.9
edited
[InstanceEdit:9861650] Stephan, Ralf, 2024年02月21日
eventOf
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:81689] pyruvate biosynthetic process
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-70523] PXLP-K314-GPT transaminates L-Ala to form PYR - Homo sapiens
[Reaction:R-HSA-71670] PKM dephosphorylates PEP to PYR - Homo sapiens
[Reaction:R-HSA-9012036] ME1 tetramer decarboxylates MAL to PYR - Homo sapiens
[Reaction:R-HSA-9861660] ME1 tetramer decarboxylates OA to PYR - Homo sapiens
[Reaction:R-HSA-70510] LDH tetramer oxidises LACT to PYR - Homo sapiens
[Reaction:R-HSA-71849] LDH tetramer reduces PYR to LACT - Homo sapiens
[Reaction:R-HSA-9861595] Cytosolic H2O2 decarboxylates PYR to acetate - Homo sapiens
[Reaction:R-HSA-9012374] VDAC1 transports PYR from cytosol to mitochondrial intermembrane space - Homo sapiens
[Reaction:R-HSA-372342] MPC1:MPC2 imports PYR, H+ to mitochondrial matrix - Homo sapiens
[Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR - Homo sapiens
[Reaction:R-HSA-9012268] ME2 tetramer decarboxylates MAL to PYR - Homo sapiens
[Reaction:R-HSA-9012349] ME3 tetramer decarboxylates MAL to PYR - Homo sapiens
[Pathway:R-HSA-9861559] PDH complex synthesizes acetyl-CoA from PYR - Homo sapiens
[Pathway:R-HSA-9861718] Regulation of pyruvate metabolism - Homo sapiens
[Reaction:R-HSA-6807826] LDHAL6B reduces PYR to LACT - Homo sapiens
[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
[Reaction:R-HSA-9861745] Mitochondrial H2O2 decarboxylates PYR to acetate - Homo sapiens
[Reaction:R-HSA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH - Homo sapiens
[Reaction:R-HSA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:374013] The glucose-lactic acid cycle and gluconeogenesis
[LiteratureReference:69983] Structure-function relationships in dihydrolipoamide acyltransferases
[LiteratureReference:9861672] The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
maxDepth
4
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Pyruvate metabolism
Cori Cycle (interconversion of glucose and lactate)
orthologousEvent
[Pathway:R-DDI-70268] Pyruvate metabolism - Dictyostelium discoideum
[Pathway:R-CFA-70268] Pyruvate metabolism - Canis familiaris
[Pathway:R-SSC-70268] Pyruvate metabolism - Sus scrofa
[Pathway:R-DRE-70268] Pyruvate metabolism - Danio rerio
[Pathway:R-XTR-70268] Pyruvate metabolism - Xenopus tropicalis
[Pathway:R-GGA-70268] Pyruvate metabolism - Gallus gallus
[Pathway:R-DME-70268] Pyruvate metabolism - Drosophila melanogaster
[Pathway:R-CEL-70268] Pyruvate metabolism - Caenorhabditis elegans
[Pathway:R-SPO-70268] Pyruvate metabolism - Schizosaccharomyces pombe
[Pathway:R-SCE-70268] Pyruvate metabolism - Saccharomyces cerevisiae
[Pathway:R-PFA-70268] Pyruvate metabolism - Plasmodium falciparum
[Pathway:R-BTA-70268] Pyruvate metabolism - Bos taurus
[Pathway:R-RNO-70268] Pyruvate metabolism - Rattus norvegicus
[Pathway:R-MMU-70268] Pyruvate metabolism - Mus musculus
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2003年02月03日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9863529] Hill, David P, 2024年03月01日
revised
[InstanceEdit:450856] D'Eustachio, P, 2009年12月18日
[InstanceEdit:9861215] Hill, David P, 2024年02月15日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-70268
summation
[Summation:70269] Pyruvate sits at an intersection of key pathways of energy m...
updateTrackers
[UpdateTracker:9780036] Update Tracker - [Pathway:70268] Pyruvate metabolism - v64:[addHasEvent, updateContainedPathway]
[UpdateTracker:9779586] Update Tracker - [Pathway:70268] Pyruvate metabolism - v65:[addHasEvent]
[UpdateTracker:9785764] Update Tracker - [Pathway:70268] Pyruvate metabolism - v51:[updateIndirectRLE]
[UpdateTracker:9784028] Update Tracker - [Pathway:70268] Pyruvate metabolism - v55:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780681] Update Tracker - [Pathway:70268] Pyruvate metabolism - v62:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9786682] Update Tracker - [Pathway:70268] Pyruvate metabolism - v49:[updateIndirectRLE]
[UpdateTracker:9792338] Update Tracker - [Pathway:70268] Pyruvate metabolism - v22:[removeHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775579] Update Tracker - [Pathway:70268] Pyruvate metabolism - v78:[updateIndirectRLE]
[UpdateTracker:9864221] Update Tracker - [Pathway:70268] Pyruvate metabolism - v88:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9780254] Update Tracker - [Pathway:70268] Pyruvate metabolism - v63:[updateIndirectRLE]
[UpdateTracker:9778331] Update Tracker - [Pathway:70268] Pyruvate metabolism - v68:[updateIndirectRLE]
[UpdateTracker:9791702] Update Tracker - [Pathway:70268] Pyruvate metabolism - v27:[addHasEvent]
[UpdateTracker:9788778] Update Tracker - [Pathway:70268] Pyruvate metabolism - v40:[updateContainedRLE]
[UpdateTracker:9791850] Update Tracker - [Pathway:70268] Pyruvate metabolism - v25:[updateContainedPathway]
[UpdateTracker:9791151] Update Tracker - [Pathway:70268] Pyruvate metabolism - v32:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9792478] Update Tracker - [Pathway:70268] Pyruvate metabolism - v20:[updateContainedPathway]
[UpdateTracker:9791744] Update Tracker - [Pathway:70268] Pyruvate metabolism - v26:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9788270] Update Tracker - [Pathway:70268] Pyruvate metabolism - v43:[updateContainedRLE]
[UpdateTracker:9784222] Update Tracker - [Pathway:70268] Pyruvate metabolism - v54:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-1428517] Aerobic respiration and respiratory electron transport
(hasEncapsulatedEvent)
[Pathway:R-HSA-9818025] NFE2L2 regulating TCA cycle genes
[Pathway:R-HSA-70326] Glucose metabolism
[Pathway:R-HSA-389661] Glyoxylate metabolism and glycine degradation
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
[Pathway:R-HSA-9857492] Protein lipoylation
(updatedInstance)
[UpdateTracker:9780036] Update Tracker - [Pathway:70268] Pyruvate metabolism - v64:[addHasEvent, updateContainedPathway]
[UpdateTracker:9779586] Update Tracker - [Pathway:70268] Pyruvate metabolism - v65:[addHasEvent]
[UpdateTracker:9785764] Update Tracker - [Pathway:70268] Pyruvate metabolism - v51:[updateIndirectRLE]
[UpdateTracker:9784028] Update Tracker - [Pathway:70268] Pyruvate metabolism - v55:[addHasEvent, updateContainedRLE]
[UpdateTracker:9780681] Update Tracker - [Pathway:70268] Pyruvate metabolism - v62:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9786682] Update Tracker - [Pathway:70268] Pyruvate metabolism - v49:[updateIndirectRLE]
[UpdateTracker:9792338] Update Tracker - [Pathway:70268] Pyruvate metabolism - v22:[removeHasEvent, updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775579] Update Tracker - [Pathway:70268] Pyruvate metabolism - v78:[updateIndirectRLE]
[UpdateTracker:9864221] Update Tracker - [Pathway:70268] Pyruvate metabolism - v88:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9780254] Update Tracker - [Pathway:70268] Pyruvate metabolism - v63:[updateIndirectRLE]
[UpdateTracker:9778331] Update Tracker - [Pathway:70268] Pyruvate metabolism - v68:[updateIndirectRLE]
[UpdateTracker:9791702] Update Tracker - [Pathway:70268] Pyruvate metabolism - v27:[addHasEvent]
[UpdateTracker:9788778] Update Tracker - [Pathway:70268] Pyruvate metabolism - v40:[updateContainedRLE]
[UpdateTracker:9791850] Update Tracker - [Pathway:70268] Pyruvate metabolism - v25:[updateContainedPathway]
[UpdateTracker:9791151] Update Tracker - [Pathway:70268] Pyruvate metabolism - v32:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9792478] Update Tracker - [Pathway:70268] Pyruvate metabolism - v20:[updateContainedPathway]
[UpdateTracker:9791744] Update Tracker - [Pathway:70268] Pyruvate metabolism - v26:[addLiteratureReference, add_removeHasEvent, modifyText]
[UpdateTracker:9788270] Update Tracker - [Pathway:70268] Pyruvate metabolism - v43:[updateContainedRLE]
[UpdateTracker:9784222] Update Tracker - [Pathway:70268] Pyruvate metabolism - v54:[addHasEvent]
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