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Entries
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
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catalystActivity
[CatalystActivity:1500600] 1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT [endoplasmic reticulum membrane]
category
transition
compartment
[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created
[InstanceEdit:75111] Gopinathrao, G, 2003年09月07日 15:00:00
dbId
75885
deleted
[Deleted:549120] Deletion of instances: 76126, 76124, 76122, 76120
displayName
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
eventOf
[Pathway:R-HSA-1483166] Synthesis of PA - Homo sapiens
followingEvent
[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Homo sapiens
[Reaction:R-HSA-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A - Homo sapiens
[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1 - Homo sapiens
[Reaction:R-HSA-75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate - Homo sapiens
[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN - Homo sapiens
input
[SimpleEntity:R-ALL-1500604] 1-acyl LPA [cytosol]
[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:200219] Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity
[LiteratureReference:200201] Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex
[LiteratureReference:549073] Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart
[LiteratureReference:549097] Acyl-CoA:lysophospholipid acyltransferases
[LiteratureReference:549085] Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
[LiteratureReference:549093] Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells
[LiteratureReference:1482531] Topology of acyltransferase motifs and substrate specificity and accessibility in 1-acyl-sn-glycero-3-phosphate acyltransferase 1
[LiteratureReference:1482565] A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation
[LiteratureReference:1482541] Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production
[LiteratureReference:1482640] Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
[LiteratureReference:2230932] Lysophospholipid acyltransferases: 1-acylglycerol-3-phosphate O-acyltransferases. From discovery to disease
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
1-acyl LPA is acylated to PA by AGPAT (LPAAT)
1-acyl-glycerol 3-phosphate + acyl-CoA => 1,2-diacyl-glycerol 3-phosphate + CoASH
lysophosphatidic acid + fatty acyl CoA => phosphatidic acid + CoA (1)
orthologousEvent
[Reaction:R-XTR-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Xenopus tropicalis
[Reaction:R-GGA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Gallus gallus
[Reaction:R-DRE-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Danio rerio
[Reaction:R-DME-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Drosophila melanogaster
[Reaction:R-CEL-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Caenorhabditis elegans
[Reaction:R-DDI-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Dictyostelium discoideum
[Reaction:R-SPO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Schizosaccharomyces pombe
[Reaction:R-SCE-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Saccharomyces cerevisiae
[Reaction:R-PFA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Plasmodium falciparum
[Reaction:R-SSC-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Sus scrofa
[Reaction:R-BTA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Bos taurus
[Reaction:R-MMU-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Mus musculus
[Reaction:R-CFA-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Canis familiaris
[Reaction:R-RNO-75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - Rattus norvegicus
output
[SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
[SimpleEntity:R-ALL-426755] PA [endoplasmic reticulum membrane]
precedingEvent
[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] - Homo sapiens
[Reaction:R-HSA-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A - Homo sapiens
[Reaction:R-HSA-75886] glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] - Homo sapiens
[Reaction:R-HSA-549112] G3P is acylated to 1-acyl LPA by AGPAT6 - Homo sapiens
[Reaction:R-HSA-75883] DHRS7B reduces GO3P to HXDG3P - Homo sapiens
[BlackBoxEvent:R-HSA-163748] Transcriptional activation of AGPAT1 by ChREBP:MLX - Homo sapiens
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-75885
summation
[Summation:178936] At the endoplasmic reticulum (ER) membrane, 1-acyl-lysophosp...
updateTrackers
[UpdateTracker:9788880] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v40:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9788663] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9790706] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v33:[addLiteratureReference, modifyText]
[UpdateTracker:9792252] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v22:[addLiteratureReference]
Referrals
(precedingEvent)
[Reaction:R-HSA-1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1]
[Reaction:R-HSA-1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A
[Reaction:R-HSA-1483203] PA is dephosphorylated to DAG by LPIN
[Reaction:R-HSA-1483121] PA is converted to CDP-DAG by CDS1
[Reaction:R-HSA-75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
(hasEvent)
[Pathway:R-HSA-1483166] Synthesis of PA
(replacementInstances)
[Deleted:549120] Deletion of instances: 76126, 76124, 76122, 76120
(updatedInstance)
[UpdateTracker:9788880] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v40:[addLiteratureReference, add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText]
[UpdateTracker:9788663] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v41:[addLiteratureReference, modifyText]
[UpdateTracker:9790706] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v33:[addLiteratureReference, modifyText]
[UpdateTracker:9792252] Update Tracker - [Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) - v22:[addLiteratureReference]
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