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Resolution of Abasic Sites (AP sites)
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authored
[InstanceEdit:110568] Matthews, L, 2004年02月03日 00:30:00
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:110568] Matthews, L, 2004年02月03日 00:30:00
dbId
73933
displayName
Resolution of Abasic Sites (AP sites)
edited
[InstanceEdit:110568] Matthews, L, 2004年02月03日 00:30:00
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014年12月03日
eventOf
[Pathway:R-HSA-73884] Base Excision Repair - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:17139] base-excision repair, gap-filling
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-110357] Displacement of DNA glycosylase by APEX1 - Homo sapiens
[Reaction:R-HSA-110359] APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site - Homo sapiens
[Pathway:R-HSA-110381] Resolution of AP sites via the single-nucleotide replacement pathway - Homo sapiens
[Pathway:R-HSA-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Homo sapiens
[Pathway:R-HSA-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年06月13日
literatureReference
[LiteratureReference:5637648] Incision activity of human apurinic endonuclease (Ape) at abasic site analogs in DNA
[LiteratureReference:111255] Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
[LiteratureReference:111250] Dynamics of the interaction of human apurinic endonuclease (Ape1) with its substrate and product.
[LiteratureReference:111257] Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein.
[LiteratureReference:111248] Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).
[LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis
[LiteratureReference:5651823] Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair
[LiteratureReference:5651761] Long patch base excision repair proceeds via coordinated stimulation of the multienzyme DNA repair complex
[LiteratureReference:176142] The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1
[LiteratureReference:5651927] The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase
[LiteratureReference:5651919] The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery
[LiteratureReference:5649703] AP endonuclease-independent DNA base excision repair in human cells
[LiteratureReference:5649714] NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
maxDepth
4
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Resolution of Abasic Sites (AP sites)
orthologousEvent
[Pathway:R-MMU-73933] Resolution of Abasic Sites (AP sites) - Mus musculus
[Pathway:R-RNO-73933] Resolution of Abasic Sites (AP sites) - Rattus norvegicus
[Pathway:R-CFA-73933] Resolution of Abasic Sites (AP sites) - Canis familiaris
[Pathway:R-BTA-73933] Resolution of Abasic Sites (AP sites) - Bos taurus
[Pathway:R-SSC-73933] Resolution of Abasic Sites (AP sites) - Sus scrofa
[Pathway:R-DRE-73933] Resolution of Abasic Sites (AP sites) - Danio rerio
[Pathway:R-XTR-73933] Resolution of Abasic Sites (AP sites) - Xenopus tropicalis
[Pathway:R-GGA-73933] Resolution of Abasic Sites (AP sites) - Gallus gallus
[Pathway:R-DME-73933] Resolution of Abasic Sites (AP sites) - Drosophila melanogaster
[Pathway:R-CEL-73933] Resolution of Abasic Sites (AP sites) - Caenorhabditis elegans
[Pathway:R-DDI-73933] Resolution of Abasic Sites (AP sites) - Dictyostelium discoideum
[Pathway:R-SPO-73933] Resolution of Abasic Sites (AP sites) - Schizosaccharomyces pombe
[Pathway:R-PFA-73933] Resolution of Abasic Sites (AP sites) - Plasmodium falciparum
releaseDate
2004年03月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5673689] Borowiec, James, 2014年12月22日
revised
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014年12月03日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-73933
summation
[Summation:212977] Resolution of AP sites can occur through the single nucleoti...
updateTrackers
[UpdateTracker:9785803] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v51:[updateIndirectRLE]
[UpdateTracker:9786450] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v49:[updateContainedPathway]
[UpdateTracker:9789714] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v37:[updateContainedPathway]
[UpdateTracker:9790556] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v33:[updateContainedPathway]
[UpdateTracker:9781942] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v60:[updateContainedPathway]
[UpdateTracker:9792020] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v24:[addSummation, updateContainedPathway]
[UpdateTracker:9779434] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v65:[updateIndirectRLE]
[UpdateTracker:9784876] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v52:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783139] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v57:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-73884] Base Excision Repair
(hasEncapsulatedEvent)
[Pathway:R-HSA-73929] Base-Excision Repair, AP Site Formation
(updatedInstance)
[UpdateTracker:9785803] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v51:[updateIndirectRLE]
[UpdateTracker:9786450] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v49:[updateContainedPathway]
[UpdateTracker:9789714] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v37:[updateContainedPathway]
[UpdateTracker:9790556] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v33:[updateContainedPathway]
[UpdateTracker:9781942] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v60:[updateContainedPathway]
[UpdateTracker:9792020] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v24:[addSummation, updateContainedPathway]
[UpdateTracker:9779434] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v65:[updateIndirectRLE]
[UpdateTracker:9784876] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v52:[addHasEvent, addLiteratureReference, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783139] Update Tracker - [Pathway:73933] Resolution of Abasic Sites (AP sites) - v57:[updateIndirectRLE]
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