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Schema
>
Reaction
>
Entries
G6PC hydrolyzes G6P to Glc and Pi (liver)
Show undefined attributes
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catalystActivity
[CatalystActivity:71824] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane]
catalystActivityReference
[CatalystActivityReference:9643168] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis
category
transition
compartment
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
crossReference
[DatabaseIdentifier:12610778] Rhea:44905
[DatabaseIdentifier:9933542] RHEA:44905
dbId
71825
displayName
G6PC hydrolyzes G6P to Glc and Pi (liver)
eventOf
[Pathway:R-HSA-70263] Gluconeogenesis - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-198458] Efflux of Glc from the endoplasmic reticulum - Homo sapiens
input
[SimpleEntity:R-ALL-113782] G6P [endoplasmic reticulum lumen]
[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:198444] Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus
[LiteratureReference:3266567] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis
[LiteratureReference:3274528] Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a
[LiteratureReference:3274546] Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
G6PC hydrolyzes G6P to Glc and Pi (liver)
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
orthologousEvent
[Reaction:R-GGA-353058] glucose 6-phosphate + H2O => glucose + phosphate - Gallus gallus
[Reaction:R-DME-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Drosophila melanogaster
[Reaction:R-GGA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Gallus gallus
[Reaction:R-XTR-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Xenopus tropicalis
[Reaction:R-SSC-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Sus scrofa
[Reaction:R-BTA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Bos taurus
[Reaction:R-CFA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Canis familiaris
[Reaction:R-RNO-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Rattus norvegicus
[Reaction:R-MMU-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Mus musculus
output
[SimpleEntity:R-ALL-113780] Glc [endoplasmic reticulum lumen]
[SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen]
precedingEvent
[Reaction:R-HSA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Homo sapiens
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:376870] Harris, RA, 2008年09月10日 18:47:12
[InstanceEdit:9815859] Hill, David P, 2022年08月29日
revised
[InstanceEdit:9815860] D'Eustachio, Peter, 2022年08月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-71825
summation
[Summation:71789] Glucose-6-phosphatase (G6PC) associated with the inner face ...
updateTrackers
[UpdateTracker:9791758] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v26:[modifyText]
[UpdateTracker:9846823] Update Tracker - [Reaction:71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - v83:[modifyText]
[UpdateTracker:9790075] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v35:[addLiteratureReference, modifyText]
[UpdateTracker:9792259] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v22:[addLiteratureReference, modifyText]
[UpdateTracker:9787247] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v46:[modifyText]
[UpdateTracker:9787427] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v45:[add_removeLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9791758] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v26:[modifyText]
[UpdateTracker:9846823] Update Tracker - [Reaction:71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - v83:[modifyText]
[UpdateTracker:9790075] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v35:[addLiteratureReference, modifyText]
[UpdateTracker:9792259] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v22:[addLiteratureReference, modifyText]
[UpdateTracker:9787247] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v46:[modifyText]
[UpdateTracker:9787427] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v45:[add_removeLiteratureReference, modifyText]
(normalReaction)
[FailedReaction:R-HSA-3274540] Defective G6PC does not hydrolyze glucose 6-phosphate
(precedingEvent)
[BlackBoxEvent:R-HSA-198458] Efflux of Glc from the endoplasmic reticulum
(hasEvent)
[Pathway:R-HSA-70263] Gluconeogenesis
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