Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
MDH2 dimer dehydrogenates MAL
Show undefined attributes
Go to Details
catalystActivity
[CatalystActivity:70978] L-malate dehydrogenase (NAD+) activity of MDH2 dimer [mitochondrial matrix]
catalystActivityReference
[CatalystActivityReference:9643763] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
category
transition
compartment
[Compartment:5460] mitochondrial matrix
crossReference
[DatabaseIdentifier:12610599] Rhea:21433
[DatabaseIdentifier:9854228] RHEA:21433
dbId
70979
displayName
MDH2 dimer dehydrogenates MAL
edited
[InstanceEdit:9859599] Stephan, Ralf, 2024年01月22日
eventOf
[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent
[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 - Homo sapiens
[Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens
[Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR - Homo sapiens
[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu - Homo sapiens
[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG - Homo sapiens
input
[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix]
[SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:451039] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
[LiteratureReference:198468] Aggregation states of mitochondrial malate dehydrogenase
[LiteratureReference:9854231] Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis
[LiteratureReference:9854217] Malate dehydrogenase 2 deficiency is an emerging cause of pediatric epileptic encephalopathy with a recognizable biochemical signature
[LiteratureReference:9854243] Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
MDH2 dimer dehydrogenates MAL
(S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
orthologousEvent
[Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ - Gallus gallus
[Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL - Danio rerio
[Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL - Rattus norvegicus
[Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus
[Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris
[Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL - Bos taurus
[Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL - Plasmodium falciparum
[Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL - Gallus gallus
[Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL - Drosophila melanogaster
[Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL - Sus scrofa
[Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL - Saccharomyces cerevisiae
[Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL - Schizosaccharomyces pombe
[Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL - Caenorhabditis elegans
[Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL - Xenopus tropicalis
output
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
[SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix]
[SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens
[Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9861215] Hill, David P, 2024年02月15日
revised
[InstanceEdit:451045] D'Eustachio, P, 2009年12月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70979
summation
[Summation:71413] Mitochondrial malate dehydrogenase (MDH2) dimer catalyzes th...
updateTrackers
[UpdateTracker:9864180] Update Tracker - [Reaction:70979] MDH2 dimer dehydrogenates MAL - v88:[addLiteratureReference, modifyText]
[UpdateTracker:9846856] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v83:[modifyText]
[UpdateTracker:9791210] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v32:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9792192] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v22:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9864180] Update Tracker - [Reaction:70979] MDH2 dimer dehydrogenates MAL - v88:[addLiteratureReference, modifyText]
[UpdateTracker:9846856] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v83:[modifyText]
[UpdateTracker:9791210] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v32:[add_removeLiteratureReference, modifyText]
[UpdateTracker:9792192] Update Tracker - [Reaction:70979] (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ - v22:[addLiteratureReference, modifyText]
(hasEvent)
[Pathway:R-HSA-9856872] Malate-aspartate shuttle
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)
[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2
[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu
[Reaction:R-HSA-70975] CS acetylates OA to citrate
[Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR
[Reaction:R-HSA-71401] OGDH dimer decarboxylates 2-OG
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル