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Schema
>
Reaction
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Entries
CS acetylates OA to citrate
Show undefined attributes
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catalystActivity
[CatalystActivity:70974] obsolete citrate (Si)-synthase activity of N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix]
category
transition
compartment
[Compartment:5460] mitochondrial matrix
crossReference
[DatabaseIdentifier:12610598] Rhea:16846
[DatabaseIdentifier:9854189] RHEA:16846
dbId
70975
displayName
CS acetylates OA to citrate
eventOf
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent
[Reaction:R-HSA-70971] ACO2 isomerizes citrate - Homo sapiens
[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL - Homo sapiens
[Reaction:R-HSA-9853512] DLST transfers succinyl to CoA - Homo sapiens
input
[SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix]
[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
[SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9853599] Complexes between mitochondrial enzymes and either citrate synthase or glutamate dehydrogenase
[LiteratureReference:198413] Cloning and molecular analysis of the human citrate synthase gene
[LiteratureReference:9854357] Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation
[LiteratureReference:198427] Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate
[LiteratureReference:9853598] Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle
[LiteratureReference:9853591] Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
CS acetylates OA to citrate
acetyl-CoA + H2O + oxaloacetate => citrate + CoA + H(+)
orthologousEvent
[Reaction:R-DRE-70975] CS acetylates OA to citrate - Danio rerio
[Reaction:R-RNO-70975] CS acetylates OA to citrate - Rattus norvegicus
[Reaction:R-MMU-70975] CS acetylates OA to citrate - Mus musculus
[Reaction:R-BTA-70975] CS acetylates OA to citrate - Bos taurus
[Reaction:R-PFA-70975] CS acetylates OA to citrate - Plasmodium falciparum
[Reaction:R-DDI-70975] CS acetylates OA to citrate - Dictyostelium discoideum
[Reaction:R-SSC-70975] CS acetylates OA to citrate - Sus scrofa
[Reaction:R-DME-70975] CS acetylates OA to citrate - Drosophila melanogaster
[Reaction:R-SCE-70975] CS acetylates OA to citrate - Saccharomyces cerevisiae
[Reaction:R-SPO-70975] CS acetylates OA to citrate - Schizosaccharomyces pombe
[Reaction:R-GGA-70975] CS acetylates OA to citrate - Gallus gallus
[Reaction:R-XTR-70975] CS acetylates OA to citrate - Xenopus tropicalis
[Reaction:R-CEL-70975] CS acetylates OA to citrate - Caenorhabditis elegans
[Reaction:R-CFA-70975] CS acetylates OA to citrate - Canis familiaris
output
[SimpleEntity:R-ALL-29654] CIT [mitochondrial matrix]
[SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix]
[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
precedingEvent
[Reaction:R-HSA-70979] MDH2 dimer dehydrogenates MAL - Homo sapiens
[Reaction:R-HSA-70844] alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA - Homo sapiens
[Reaction:R-HSA-9854315] CSKMT methylates Citrate Synthase - Homo sapiens
[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9861215] Hill, David P, 2024年02月15日
revised
[InstanceEdit:451045] D'Eustachio, P, 2009年12月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70975
summation
[Summation:71414] Mitochondrial citrate synthase (CS) dimer catalyzes the irre...
updateTrackers
[UpdateTracker:9792277] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v22:[addLiteratureReference, modifyText]
[UpdateTracker:9791124] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v32:[addLiteratureReference, modifyText]
[UpdateTracker:9864128] Update Tracker - [Reaction:70975] CS acetylates OA to citrate - v88:[addLiteratureReference, addOutput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9792277] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v22:[addLiteratureReference, modifyText]
[UpdateTracker:9791124] Update Tracker - [Reaction:70975] Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA - v32:[addLiteratureReference, modifyText]
[UpdateTracker:9864128] Update Tracker - [Reaction:70975] CS acetylates OA to citrate - v88:[addLiteratureReference, addOutput, modifyText]
(hasEvent)
[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(precedingEvent)
[Reaction:R-HSA-9853512] DLST transfers succinyl to CoA
[Reaction:R-HSA-70971] ACO2 isomerizes citrate
[Reaction:R-HSA-75849] SLC25A1 exchanges CIT and MAL
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