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Schema
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Entries
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
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catalystActivity
[CatalystActivity:70419] glucokinase activity of glucokinase and hexokinases [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
crossReference
[DatabaseIdentifier:9933515] RHEA:17826
[DatabaseIdentifier:12610570] Rhea:36496
dbId
70420
deleted
[Deleted:622426] Deletion of instance: 500039
[Deleted:450107] Deletion of instance: 70114
[Deleted:450105] Deletion of instances: 70414, 70397, 70380
[Deleted:622430] Deletion of instance: 500039
displayName
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
eventOf
[Pathway:R-HSA-70171] Glycolysis - Homo sapiens
followingEvent
[Reaction:R-HSA-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP - Homo sapiens
[Reaction:R-HSA-70471] GPI dimer isomerizes G6P - Homo sapiens
[Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P - Homo sapiens
[Reaction:R-HSA-9638127] PGM1:Mg2+ isomerises G6P to G1P - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-70113] Glc [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199694] The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate
[LiteratureReference:9820637] Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1
[LiteratureReference:199692] Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity
[LiteratureReference:9828521] Hepatic HKDC1 Expression Contributes to Liver Metabolism
[LiteratureReference:199700] Compartmentation of hexokinase in human blood cells. Characterization of soluble and particulate enzymes.
[LiteratureReference:199710] Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
[LiteratureReference:391483] Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs
[LiteratureReference:264743] GLUT2 in pancreatic and extra-pancreatic gluco-detection (review)
[LiteratureReference:9828532] Hexokinase domain-containing protein-1 in metabolic diseases and beyond
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
orthologousEvent
[Reaction:R-MMU-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Mus musculus
[Reaction:R-RNO-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Rattus norvegicus
[Reaction:R-CFA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Canis familiaris
[Reaction:R-BTA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Bos taurus
[Reaction:R-SSC-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Sus scrofa
[Reaction:R-XTR-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Xenopus tropicalis
[Reaction:R-GGA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Gallus gallus
[Reaction:R-DME-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Drosophila melanogaster
[Reaction:R-CEL-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Caenorhabditis elegans
[Reaction:R-SPO-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Schizosaccharomyces pombe
[Reaction:R-SCE-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Saccharomyces cerevisiae
[Reaction:R-PFA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Plasmodium falciparum
[Reaction:R-DRE-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Danio rerio
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-30537] G6P [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-211346] NEUROD1- and PDX1-dependent synthesis of glucokinase (GCK) protein - Homo sapiens
releaseDate
2004年07月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9820651] Hill, David P, 2022年11月18日
revised
[InstanceEdit:450087] D'Eustachio, P, 2009年12月11日
[InstanceEdit:9820650] D'Eustachio, Peter, 2022年11月17日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-70420
summation
[Summation:391482] Cytosolic glucokinase and the three isoforms of hexokinase c...
updateTrackers
[UpdateTracker:9791584] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v28:[addLiteratureReference, add_removeSummation]
[UpdateTracker:9777234] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v72:[addOutput]
[UpdateTracker:9790504] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v33:[addLiteratureReference, modifyText]
[UpdateTracker:9791235] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v32:[addLiteratureReference, modifyText]
[UpdateTracker:9846610] Update Tracker - [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - v84:[addLiteratureReference, modifyText]
[UpdateTracker:9792318] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v22:[addLiteratureReference]
Referrals
(precedingEvent)
[Reaction:R-HSA-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP
[Reaction:R-HSA-70471] GPI dimer isomerizes G6P
[Reaction:R-HSA-70377] G6PD multimers dehydrogenate G6P
[Reaction:R-HSA-9638127] PGM1:Mg2+ isomerises G6P to G1P
(hasEvent)
[Pathway:R-HSA-70171] Glycolysis
(normalReaction)
[FailedReaction:R-HSA-5621888] Defective HK1 does not phosphorylate Glc to form G6P
[FailedReaction:R-HSA-5621918] Defective GCK does not phosphorylate Glc to form G6P
(replacementInstances)
[Deleted:622426] Deletion of instance: 500039
[Deleted:450107] Deletion of instance: 70114
[Deleted:450105] Deletion of instances: 70414, 70397, 70380
[Deleted:622430] Deletion of instance: 500039
(updatedInstance)
[UpdateTracker:9791584] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v28:[addLiteratureReference, add_removeSummation]
[UpdateTracker:9777234] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v72:[addOutput]
[UpdateTracker:9790504] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v33:[addLiteratureReference, modifyText]
[UpdateTracker:9791235] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v32:[addLiteratureReference, modifyText]
[UpdateTracker:9846610] Update Tracker - [Reaction:70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - v84:[addLiteratureReference, modifyText]
[UpdateTracker:9792318] Update Tracker - [Reaction:70420] HK1,2,3,GCK phosphorylate Glc to form G6P - v22:[addLiteratureReference]
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