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Inactivation of Cyclin E:Cdk2 complexes by p27/p21 Show undefined attributes

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catalystActivity

[CatalystActivity:188223] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]

category transition

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:69508] Khanna, K, 2003年06月05日 08:03:38

dbId 69562

deleted

displayName Inactivation of Cyclin E:Cdk2 complexes by p27/p21

edited

eventOf

[Pathway:R-HSA-69563] p53-Dependent G1 DNA Damage Response - Homo sapiens
[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens
[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens

figure

[Figure:69455] /figures/p53_dep_inactivation.jpg

followingEvent

[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Inactivation of Cyclin E:Cdk2 complexes by p27/p21

orthologousEvent

output

[Complex:R-HSA-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm]

precedingEvent

releaseDate 2004年07月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

[InstanceEdit:188183] Matthews, L, 2006年10月02日 06:19:16

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-69562

summation

[Summation:187795] During G1, the activity of cyclin-dependent kinases (CDKs) i...

updateTrackers

Referrals

(updatedInstance)

(replacementInstances)

(hasEvent)

(precedingEvent)

[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

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