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Schema
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Reaction
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Entries
BRAF and RAF fusion mutant dimers are phosphorylated
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authored
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
catalystActivity
[CatalystActivity:5672970] protein serine/threonine/tyrosine kinase activity of RAF activating kinases [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:6802928] Rothfels, Karen, 2015年10月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
6802927
disease
[Disease:1500689] cancer
displayName
BRAF and RAF fusion mutant dimers are phosphorylated
edited
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
entityFunctionalStatus
[EntityFunctionalStatus:6802860] gain_of_function of BRAF/RAF fusion dimers [cytosol]
eventOf
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions - Homo sapiens
followingEvent
[Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[CandidateSet:R-HSA-6802720] BRAF/RAF fusion dimers [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:6800638] Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
[LiteratureReference:6800633] Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma
[LiteratureReference:6800635] Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma
[LiteratureReference:6802072] Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer
[LiteratureReference:6800639] The landscape of kinase fusions in cancer
[LiteratureReference:6800632] BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
[LiteratureReference:6802135] Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
[LiteratureReference:6800629] A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
[LiteratureReference:6802031] Identification of kinase fusion oncogenes in post-Chernobyl radiation-induced thyroid cancers
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
BRAF and RAF fusion mutant dimers are phosphorylated
normalReaction
[Reaction:R-HSA-5672969] Phosphorylation of RAF
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[CandidateSet:R-HSA-6802698] p-BRAF/RAF fusion dimers [cytosol]
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6802927
summation
[Summation:6802195] Fusion mutants of BRAF and RAF1 are believed to form constit...
Referrals
(hasEvent)
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions
(precedingEvent)
[Reaction:R-HSA-6802934] p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs
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