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Schema
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Entries
TNFR2 non-canonical NF-kB pathway
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authored
[InstanceEdit:5668484] Garapati, Phani Vijay, 2015年01月26日
compartment
[Compartment:876] plasma membrane
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5668515] Garapati, Phani Vijay, 2015年01月26日
dbId
5668541
displayName
TNFR2 non-canonical NF-kB pathway
doi
10.3180/r-hsa-5668541.1
edited
[InstanceEdit:5668484] Garapati, Phani Vijay, 2015年01月26日
eventOf
[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:261164] tumor necrosis factor-mediated signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-5668543] TRAF3:NIK binds TRAF2:cIAP1/2 - Homo sapiens
[BlackBoxEvent:R-HSA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Homo sapiens
[BlackBoxEvent:R-HSA-5668520] 26Sproteasome degrades K48polyUb-NIK - Homo sapiens
[Reaction:R-HSA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Homo sapiens
[Reaction:R-HSA-5668404] TNFA binds TNFR2 - Homo sapiens
[Reaction:R-HSA-5668467] 2xTNFR2 binds TNFA trimer:TNFR2 - Homo sapiens
[Reaction:R-HSA-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer - Homo sapiens
[Pathway:R-HSA-5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway - Homo sapiens
[BlackBoxEvent:R-HSA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Homo sapiens
[BlackBoxEvent:R-HSA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 - Homo sapiens
[BlackBoxEvent:R-HSA-5668481] Protesomal degradation of K48polyUb-TRAF3 - Homo sapiens
[Pathway:R-HSA-5676590] NIK-->noncanonical NF-kB signaling - Homo sapiens
[Pathway:R-HSA-5669034] TNFs bind their physiological receptors - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年09月14日
literatureReference
[LiteratureReference:5668587] TNF receptor 2 pathway: drug target for autoimmune diseases
[LiteratureReference:5668590] Tumor necrosis factor receptor cross-talk
[LiteratureReference:5668539] Non-canonical NF-kB signaling pathway
[LiteratureReference:5668923] Non-canonical NF-?B signaling activation and regulation: principles and perspectives
[LiteratureReference:5686423] Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs
[LiteratureReference:5686416] Non-Canonical NF-?B Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures
[LiteratureReference:5686419] CD40-Mediated Activation of the NF-?B2 Pathway
maxDepth
3
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
TNFR2 non-canonical NF-kB pathway
TNFRSF mediated non-canonical NF-kB pathway
orthologousEvent
[Pathway:R-SCE-5668541] TNFR2 non-canonical NF-kB pathway - Saccharomyces cerevisiae
[Pathway:R-DME-5668541] TNFR2 non-canonical NF-kB pathway - Drosophila melanogaster
[Pathway:R-GGA-5668541] TNFR2 non-canonical NF-kB pathway - Gallus gallus
[Pathway:R-XTR-5668541] TNFR2 non-canonical NF-kB pathway - Xenopus tropicalis
[Pathway:R-DRE-5668541] TNFR2 non-canonical NF-kB pathway - Danio rerio
[Pathway:R-SSC-5668541] TNFR2 non-canonical NF-kB pathway - Sus scrofa
[Pathway:R-BTA-5668541] TNFR2 non-canonical NF-kB pathway - Bos taurus
[Pathway:R-CFA-5668541] TNFR2 non-canonical NF-kB pathway - Canis familiaris
[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
[Pathway:R-MMU-5668541] TNFR2 non-canonical NF-kB pathway - Mus musculus
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5692509] Ware, Carl F, Virgen-Slane, Richard, Rajput, Akhil, 2015年05月12日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5668541
summation
[Summation:5668544] Tumor necrosis factor-alpha (TNFA) exerts a wide range of bi...
updateTrackers
[UpdateTracker:9847076] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v82:[addHasEvent]
[UpdateTracker:9782719] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v58:[updateContainedPathway]
[UpdateTracker:9782365] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v59:[updateContainedPathway, updateIndirectRLE]
Referrals
(updatedInstance)
[UpdateTracker:9847076] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v82:[addHasEvent]
[UpdateTracker:9782719] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v58:[updateContainedPathway]
[UpdateTracker:9782365] Update Tracker - [Pathway:5668541] TNFR2 non-canonical NF-kB pathway - v59:[updateContainedPathway, updateIndirectRLE]
(hasEvent)
[Pathway:R-HSA-1280215] Cytokine Signaling in Immune system
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