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Entries
FRS-mediated FGFR1 signaling
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
created
[InstanceEdit:5654691] Rothfels, Karen, 2014年12月03日
crossReference
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
dbId
5654693
deleted
[Deleted:5655580] Deletion of instance: 190345
displayName
FRS-mediated FGFR1 signaling
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5654569] Activated FGFR1 binds FRS2 - Homo sapiens
[Reaction:R-HSA-5654571] Activated FGFR1 binds FRS3 - Homo sapiens
[Reaction:R-HSA-5654575] Activated FGFR1 phosphorylates FRS2 - Homo sapiens
[Reaction:R-HSA-5654578] Activated FGFR1 phosphorylates FRS3 - Homo sapiens
[Reaction:R-HSA-5654586] Activated FGFR1:p-FRS binds GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-5654584] Activated FGFR1:p-FRS bind to PPTN11 - Homo sapiens
[Reaction:R-HSA-5654587] Activated FGFR1:p-FRS phosphorylates PPTN11 - Homo sapiens
[Reaction:R-HSA-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016年12月21日
literatureReference
[LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
[LiteratureReference:191015] Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways
[LiteratureReference:191490] Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells
[LiteratureReference:1549556] Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
FRS-mediated FGFR1 signaling
orthologousEvent
[Pathway:R-MMU-5654693] FRS-mediated FGFR1 signaling - Mus musculus
[Pathway:R-CEL-5654693] FRS-mediated FGFR1 signaling - Caenorhabditis elegans
[Pathway:R-DME-5654693] FRS-mediated FGFR1 signaling - Drosophila melanogaster
[Pathway:R-GGA-5654693] FRS-mediated FGFR1 signaling - Gallus gallus
[Pathway:R-XTR-5654693] FRS-mediated FGFR1 signaling - Xenopus tropicalis
[Pathway:R-DRE-5654693] FRS-mediated FGFR1 signaling - Danio rerio
[Pathway:R-SSC-5654693] FRS-mediated FGFR1 signaling - Sus scrofa
[Pathway:R-BTA-5654693] FRS-mediated FGFR1 signaling - Bos taurus
[Pathway:R-CFA-5654693] FRS-mediated FGFR1 signaling - Canis familiaris
[Pathway:R-RNO-5654693] FRS-mediated FGFR1 signaling - Rattus norvegicus
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5654693
summation
[Summation:191017] The FRS family of scaffolding adaptor proteins has two membe...
updateTrackers
[UpdateTracker:9782686] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9782840] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v58:[removeHasEvent]
[UpdateTracker:9783532] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v56:[updateContainedPathway]
[UpdateTracker:9784773] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v53:[add_removeHasEvent]
Referrals
(updatedInstance)
[UpdateTracker:9782686] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v59:[addHasEvent, updateContainedRLE]
[UpdateTracker:9782840] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v58:[removeHasEvent]
[UpdateTracker:9783532] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v56:[updateContainedPathway]
[UpdateTracker:9784773] Update Tracker - [Pathway:5654693] FRS-mediated FGFR1 signaling - v53:[add_removeHasEvent]
(replacementInstances)
[Deleted:5655580] Deletion of instance: 190345
(hasEvent)
[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1
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