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Schema
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Pathway
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Entries
PI-3K cascade:FGFR1
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authored
[InstanceEdit:190908] de Bono, B, 2007年01月10日 10:27:18
created
[InstanceEdit:5654691] Rothfels, Karen, 2014年12月03日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757952] BioModels Database:BIOMD0000000581
[DatabaseIdentifier:12757954] BioModels Database:BIOMD0000000724
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
dbId
5654689
deleted
[Deleted:5655574] Deletion of instance: 190926
displayName
PI-3K cascade:FGFR1
edited
[InstanceEdit:500337] Jupe, S, 2010年02月03日
eventOf
[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-177931] Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 - Homo sapiens
[Reaction:R-HSA-5654592] Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 - Homo sapiens
[Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens
[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-5654594] Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 - Homo sapiens
[Reaction:R-HSA-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
[Reaction:R-HSA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2018年03月26日
literatureReference
[LiteratureReference:191050] Cell signaling by receptor tyrosine kinases
[LiteratureReference:191055] The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival
[LiteratureReference:191057] The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells
[LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
[LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
PI-3K cascade:FGFR1
orthologousEvent
[Pathway:R-MMU-5654689] PI-3K cascade:FGFR1 - Mus musculus
[Pathway:R-CEL-5654689] PI-3K cascade:FGFR1 - Caenorhabditis elegans
[Pathway:R-DME-5654689] PI-3K cascade:FGFR1 - Drosophila melanogaster
[Pathway:R-GGA-5654689] PI-3K cascade:FGFR1 - Gallus gallus
[Pathway:R-XTR-5654689] PI-3K cascade:FGFR1 - Xenopus tropicalis
[Pathway:R-DRE-5654689] PI-3K cascade:FGFR1 - Danio rerio
[Pathway:R-SSC-5654689] PI-3K cascade:FGFR1 - Sus scrofa
[Pathway:R-BTA-5654689] PI-3K cascade:FGFR1 - Bos taurus
[Pathway:R-CFA-5654689] PI-3K cascade:FGFR1 - Canis familiaris
[Pathway:R-RNO-5654689] PI-3K cascade:FGFR1 - Rattus norvegicus
releaseDate
2010年03月16日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192607] Mohammadi, M, 2007年02月06日 21:44:35
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5654689
summation
[Summation:191044] The ability of growth factors to protect from apoptosis is p...
updateTrackers
[UpdateTracker:9782904] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v58:[removeHasEvent]
[UpdateTracker:9780070] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v64:[updateContainedRLE]
[UpdateTracker:9783572] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v56:[updateContainedPathway]
[UpdateTracker:9784066] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v54:[updateIndirectRLE]
[UpdateTracker:9783833] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v55:[updateIndirectRLE]
Referrals
(updatedInstance)
[UpdateTracker:9782904] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v58:[removeHasEvent]
[UpdateTracker:9780070] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v64:[updateContainedRLE]
[UpdateTracker:9783572] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v56:[updateContainedPathway]
[UpdateTracker:9784066] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v54:[updateIndirectRLE]
[UpdateTracker:9783833] Update Tracker - [Pathway:5654689] PI-3K cascade:FGFR1 - v55:[updateIndirectRLE]
(replacementInstances)
[Deleted:5655574] Deletion of instance: 190926
(hasEvent)
[Pathway:R-HSA-5654687] Downstream signaling of activated FGFR1
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