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Schema
>
Reaction
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Entries
Activated FGFR4 binds FRS2
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authored
[InstanceEdit:1489508] Rothfels, K, 2011年08月15日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5654421] Rothfels, Karen, 2014年12月03日
dbId
5654422
deleted
[Deleted:5655573] Deletion of instance: 1268220
displayName
Activated FGFR4 binds FRS2
eventOf
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling - Homo sapiens
followingEvent
[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2 - Homo sapiens
input
[DefinedSet:R-HSA-5654158] Activated FGFR4 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-170963] FRS2 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
[LiteratureReference:532259] Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
[LiteratureReference:1268074] Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Activated FGFR4 binds FRS2
orthologousEvent
[Reaction:R-RNO-5654422] Activated FGFR4 binds FRS2 - Rattus norvegicus
[Reaction:R-DME-5654422] Activated FGFR4 binds FRS2 - Drosophila melanogaster
[Reaction:R-GGA-5654422] Activated FGFR4 binds FRS2 - Gallus gallus
[Reaction:R-XTR-5654422] Activated FGFR4 binds FRS2 - Xenopus tropicalis
[Reaction:R-SSC-5654422] Activated FGFR4 binds FRS2 - Sus scrofa
[Reaction:R-BTA-5654422] Activated FGFR4 binds FRS2 - Bos taurus
[Reaction:R-CFA-5654422] Activated FGFR4 binds FRS2 - Canis familiaris
[Reaction:R-MMU-5654422] Activated FGFR4 binds FRS2 - Mus musculus
output
[Complex:R-HSA-5654182] Activated FGFR4:FRS2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-190326] Autocatalytic phosphorylation of FGFR4 - Homo sapiens
[Reaction:R-HSA-1307963] Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 - Homo sapiens
releaseDate
2011年09月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1549563] Gotoh, N, 2011年08月26日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5654422
summation
[Summation:1268219] FRS2 (also known as FRS2alpha) is broadly expressed in adult...
Referrals
(replacementInstances)
[Deleted:5655573] Deletion of instance: 1268220
(normalReaction)
[Reaction:R-HSA-5655351] Activated FGFR4 mutants bind FRS2
(hasEvent)
[Pathway:R-HSA-5654712] FRS-mediated FGFR4 signaling
(precedingEvent)
[Reaction:R-HSA-5654418] Activated FGFR4 phosphorylates FRS2
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