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Schema
>
BlackBoxEvent
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Entries
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3
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authored
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014年12月26日
category
omitted
compartment
[Compartment:984] extracellular region
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5625880] Orlic-Milacic, Marija, 2014年10月08日
dbId
5625883
displayName
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3
edited
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014年10月24日
eventOf
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Homo sapiens
followingEvent
[Reaction:R-HSA-1604722] Activation of proMMP9 by proteases - Homo sapiens
[BlackBoxEvent:R-HSA-1592398] Activation of proMMP8 - Homo sapiens
[Reaction:R-HSA-381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS - Homo sapiens
input
[DefinedSet:R-HSA-5625769] KLK2,3 genes [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
PKN1 in complex with AR positively regulates expression of KLK2 and KLK3
output
[DefinedSet:R-HSA-5625882] KLK2,KLK3 [extracellular region]
precedingEvent
[Reaction:R-HSA-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
regulatedBy
[PositiveRegulation:R-HSA-5625881] Positive regulation by 'p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm]'
regulationReference
[RegulationReference:9642891] Positive regulation by 'p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3 [nucleoplasm]' Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-5625883
summation
[Summation:5627291] PKN1-facilitated demethylation of histones at promoters of K...
systematicName
KLK2,3 genes express KLK2,3 proteins
Referrals
(hasEvent)
[Pathway:R-HSA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(precedingEvent)
[Reaction:R-HSA-381466] Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
[Reaction:R-HSA-1604722] Activation of proMMP9 by proteases
[BlackBoxEvent:R-HSA-1592398] Activation of proMMP8
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