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Schema
>
FailedReaction
>
Entries
Defective MyD88 does not oligomerize within the complex of activated TLR5
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authored
[InstanceEdit:5545427] Shamovsky, V, 2014年05月21日
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:5602721] Shamovsky, Veronica, 2014年06月24日
crossReference
[DatabaseIdentifier:11945161] Mondo:0003778
dbId
5602316
disease
[Disease:5228860] primary immunodeficiency disease
displayName
Defective MyD88 does not oligomerize within the complex of activated TLR5
edited
[InstanceEdit:5673719] Shamovsky, Veronica, 2015年02月09日
entityFunctionalStatus
[EntityFunctionalStatus:5602376] loss_of_function of MyD88 variants [cytosol]
[EntityFunctionalStatus:9658484] loss_of_function of MyD88 variant:TLR5:bacterial flagellin [plasma membrane]
eventOf
[Pathway:R-HSA-5602680] MyD88 deficiency (TLR5) - Homo sapiens
input
[Complex:R-HSA-9037690] MyD88 variant:TLR5:bacterial flagellin [plasma membrane]
4 ×
[CandidateSet:R-HSA-5602754] MyD88 variants [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5602389] Pyogenic bacterial infections in humans with MyD88 deficiency
[LiteratureReference:2428864] Two human MYD88 variants, S34Y and R98C, interfere with MyD88-IRAK4-myddosome assembly
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Defective MyD88 does not oligomerize within the complex of activated TLR5
normalReaction
[Reaction:R-HSA-975880] MyD88 oligomerization within the complex of activated TLR:MyD88
relatedSpecies
[Species:159879] Escherichia coli
releaseDate
2015年03月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5621924] D'Eustachio, Peter, 2014年09月06日
[InstanceEdit:5675062] McDonald, Douglas R, 2015年02月15日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5602316
summation
[Summation:5607932] TLR5 employs the MyD88-dependent signaling pathway. An autos...
systematicName
Defective MyD88 variants do not form a complex with IRAK4, TLR5 homodimer:bacterial flagellin
updateTrackers
[UpdateTracker:9780090] Update Tracker - [FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - v64:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9780090] Update Tracker - [FailedReaction:5602316] Defective MyD88 does not oligomerize within the complex of activated TLR5 - v64:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-5602680] MyD88 deficiency (TLR5)
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