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Schema
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FailedReaction
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Entries
APC truncation mutants have impaired AXIN binding
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authored
[InstanceEdit:4663888] Rothfels, K, 2013年10月07日
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:4791277] Rothfels, K, 2013年10月28日
crossReference
[DatabaseIdentifier:11944899] Mondo:0005575
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
4791278
disease
[Disease:1500689] cancer
[Disease:4791250] colorectal cancer
displayName
APC truncation mutants have impaired AXIN binding
edited
[InstanceEdit:5358774] Matthews, Lisa, 2014年04月03日
entityFunctionalStatus
[EntityFunctionalStatus:4791276] loss_of_function of APC truncation mutants [cytosol]
eventOf
[Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-1504189] AMER1 [cytosol]
[CandidateSet:R-HSA-4791256] APC truncation mutants [cytosol]
[EntityWithAccessionedSequence:R-HSA-195249] AXIN1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-195263] CSNK1A1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-2997551] GSK3B [cytosol]
[Complex:R-HSA-196206] PP2A [cytosol]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:3299516] Functional interaction of beta-catenin with the transcription factor LEF-1
[LiteratureReference:5246628] Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin
[LiteratureReference:5246631] Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta
[LiteratureReference:5246624] Association of the APC gene product with beta-catenin
[LiteratureReference:5246629] Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly
[LiteratureReference:5246626] Association of the APC tumor suppressor protein with catenins
[LiteratureReference:3238089] The way Wnt works: Components and mechanism
[LiteratureReference:5246618] Wnt signaling and cancer
[LiteratureReference:5246620] Wnt signaling in cancer
[LiteratureReference:5246621] Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
[LiteratureReference:5246639] The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression
[LiteratureReference:5246637] Suppression of beta-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
APC truncation mutants have impaired AXIN binding
normalReaction
[Reaction:R-HSA-195251] Assembly of the destruction complex
releaseDate
2014年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5433076] Salahshor, S, 2014年05月12日
[InstanceEdit:5545509] Woodgett, Jim, 2014年05月21日
schemaClass
FailedReaction
species
[Species:48887] Homo sapiens
stId
R-HSA-4791278
summation
[Summation:5246643] The tumor suppressor APC is a central component of the destr...
Referrals
(hasEvent)
[Pathway:R-HSA-5467337] APC truncation mutants have impaired AXIN binding
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