Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

TGFBR2 K128Sfs*35 [cytosol] Show undefined attributes

compartment

[Compartment:70101] cytosol

created [InstanceEdit:3642147] Orlic-Milacic, M, 2013年05月30日

crossReference

dbId 3642166

disease

displayName TGFBR2 K128Sfs*35 [cytosol]

endCoordinate 161

hasModifiedResidue

[FragmentReplacedModification:9831643] Replacement of residues 128 to 161 by SLVRLSSCVPVALMSAMTTSSSQKNITPAILTCC

inDisease true

literatureReference

[LiteratureReference:3642171] Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
[LiteratureReference:3642192] Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells

maxDepth 1

memberOf

[DefinedSet:R-HSA-3642198] TGFBR2 MSI frameshift mutants [cytosol] - Homo sapiens

modified [InstanceEdit:9831645] Orlic-Milacic, Marija, 2023年03月23日

name

TGFBR2 K128Sfs*35
TGFBR2 Lys128Serfs*35

referenceEntity [ReferenceGeneProduct:uniprot:P37173] UniProt:P37173 TGFBR2

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-3642166

startCoordinate 23

updateTrackers

[UpdateTracker:9905271] Update Tracker - [EntityWithAccessionedSequence:3642166] TGFBR2 K128Sfs*35 [cytosol] - v85:[add_removeHasModifiedResidue, modifyName]

Referrals

(updatedInstance)

[UpdateTracker:9905271] Update Tracker - [EntityWithAccessionedSequence:3642166] TGFBR2 K128Sfs*35 [cytosol] - v85:[add_removeHasModifiedResidue, modifyName]

(hasMember)

[DefinedSet:R-HSA-3642198] TGFBR2 MSI frameshift mutants [cytosol]

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