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Integrin cell surface interactions
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authored
[InstanceEdit:266384] Geiger, B, Horwitz, R, 2008年05月07日 08:30:32
[InstanceEdit:2426629] Jupe, S, 2012年08月08日
created
[InstanceEdit:216084] Garapati, P V, 2008年03月11日 10:20:45
dbId
216083
displayName
Integrin cell surface interactions
doi
10.3180/REACT_13552.1
edited
[InstanceEdit:216084] Garapati, P V, 2008年03月11日 10:20:45
[InstanceEdit:4090280] Jupe, S, 2013年08月13日
eventOf
[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization - Homo sapiens
figure
[Figure:2291893] /figures/Pathway_Illustrations/Integrin_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:20745] extracellular matrix organization
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-2327695] Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 - Homo sapiens
[Reaction:R-HSA-114563] Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1 - Homo sapiens
[Reaction:R-HSA-216045] Collagen type I binds integrin alpha11beta1 - Homo sapiens
[Reaction:R-HSA-4084910] Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1 - Homo sapiens
[Reaction:R-HSA-216043] Collagen type II binds integrin alpha10beta1 - Homo sapiens
[Reaction:R-HSA-216040] Collagen type IV networks bind integrins alpha1beta1, alpha2beta1 - Homo sapiens
[Reaction:R-HSA-4086216] Collagen type VII binds integrin alpha2beta1 - Homo sapiens
[Reaction:R-HSA-2470555] Collagen type X binds Integrin alpha2beta1 - Homo sapiens
[Reaction:R-HSA-2484965] Collagen type XIII binds Integrin alpha1beta1 - Homo sapiens
[Reaction:R-HSA-2473511] Collagen type XXIII binds Integrin alpha2beta1 - Homo sapiens
[Reaction:R-HSA-4084903] Collagen types VI, IX bind integrin alpha10beta1 - Homo sapiens
[Reaction:R-HSA-4539779] Collagen type IV binds integrin alpha10beta1 - Homo sapiens
[Reaction:R-HSA-4086223] Collagen type IX binds integrin alpha11beta1 - Homo sapiens
[Reaction:R-HSA-4084912] Arresten binds integrin alpha1beta1 - Homo sapiens
[Reaction:R-HSA-4088264] Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1 - Homo sapiens
[Reaction:R-HSA-4085083] Tumstatin binds integrin alphaVbeta 3, alpha3beta1 - Homo sapiens
[Reaction:R-HSA-4085087] Canstatin binds integrins alphaVbeta3, alphaVbeta5 - Homo sapiens
[Reaction:R-HSA-4088218] Tetrastatin binds integrin alphaVbeta3 - Homo sapiens
[Reaction:R-HSA-265429] THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 - Homo sapiens
[Reaction:R-HSA-216050] Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix - Homo sapiens
[Reaction:R-HSA-265424] SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1 - Homo sapiens
[Reaction:R-HSA-2752118] SPP1 (osteopontin) binds Integrin alpha4beta1 - Homo sapiens
[Reaction:R-HSA-216061] SPP1 (osteopontin) binds integrin alpha8beta1 - Homo sapiens
[Reaction:R-HSA-2752125] SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 - Homo sapiens
[Reaction:R-HSA-2752115] SPP1 (osteopontin) binds CD44 - Homo sapiens
[Reaction:R-HSA-198941] VCAM1 binds Integrin alpha4beta1 - Homo sapiens
[Reaction:R-HSA-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Homo sapiens
[Reaction:R-HSA-9679740] ITGA4:ITGB1 binds natalizumab - Homo sapiens
[Reaction:R-HSA-199032] MADCAM1-1 binds Integrin alpha4beta7 - Homo sapiens
[Reaction:R-HSA-216064] Interaction of integrin alpha8beta1 with Tenascin-C - Homo sapiens
[Reaction:R-HSA-265428] Interaction of integrin alpha9beta1 with VCAM1 - Homo sapiens
[Reaction:R-HSA-216068] Interaction of integrin alpha9beta1 with Tenascin-C - Homo sapiens
[Reaction:R-HSA-216069] Interaction of integrin alphaDbeta2 with fibrin - Homo sapiens
[Reaction:R-HSA-216082] Interaction of integrin alphaXbeta2 with fibrin - Homo sapiens
[Reaction:R-HSA-216076] VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8 - Homo sapiens
[Reaction:R-HSA-202704] Integrin alphaXbeta2 binds JAM3 - Homo sapiens
[Reaction:R-HSA-199050] ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) - Homo sapiens
[Reaction:R-HSA-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Homo sapiens
[Reaction:R-HSA-202727] Integrin alphaMbeta2 (MAC1) binds JAM3 - Homo sapiens
[Reaction:R-HSA-204434] BSG (basigin) binds Integrin alpha3beta1, alpha6beta1 - Homo sapiens
[Reaction:R-HSA-265427] Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2) - Homo sapiens
[Reaction:R-HSA-265426] Interaction of integrin alphaVbeta3 with Tenascin - Homo sapiens
[Reaction:R-HSA-265423] Interaction of integrin alphaVbeta3 with Fibrillin - Homo sapiens
[Reaction:R-HSA-265425] Interaction of integrin alphaVbeta3 with von Willbrand Factor - Homo sapiens
[Reaction:R-HSA-210304] Interaction of integrin alphaVbeta3 with PECAM1 - Homo sapiens
[Reaction:R-HSA-265422] Interaction of integrin alphaEbeta7 with Cadherin-1 - Homo sapiens
[Reaction:R-HSA-349593] Interaction of integrin alphaIIbbeta3 with Fibronectin - Homo sapiens
[Reaction:R-HSA-114560] Adhesion of integrin ?IIb?3 to fibrin network - Homo sapiens
[Reaction:R-HSA-216072] Interaction of integrin alphaIIbbeta3 with von Willebrand factor - Homo sapiens
[Reaction:R-HSA-349603] Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1) - Homo sapiens
[Reaction:R-HSA-4085133] LUM (lumican) binds integrin alpha2beta1 - Homo sapiens
[Reaction:R-HSA-2467436] AGRN binds Integrins alphaVbeta1 (Other beta1-containing integrins) - Homo sapiens
[Reaction:R-HSA-2426259] COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 - Homo sapiens
[Reaction:R-HSA-4088281] Endorepellin binds KDR (VEGFR2) - Homo sapiens
[Reaction:R-HSA-4088220] Endorepellin binds alpha2beta1 integrin - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2020年09月24日
literatureReference
[LiteratureReference:215812] Inside-out signaling through integrins
[LiteratureReference:215877] Coming to grips with integrin binding to ligands
[LiteratureReference:215810] The collagen receptor subfamily of the integrins
[LiteratureReference:3000176] Extracellular matrix and integrin signalling: the shape of things to come
[LiteratureReference:3000183] Integrins and proximal signaling mechanisms in cardiovascular disease
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Integrin cell surface interactions
orthologousEvent
[Pathway:R-CEL-216083] Integrin cell surface interactions - Caenorhabditis elegans
[Pathway:R-DME-216083] Integrin cell surface interactions - Drosophila melanogaster
[Pathway:R-GGA-216083] Integrin cell surface interactions - Gallus gallus
[Pathway:R-XTR-216083] Integrin cell surface interactions - Xenopus tropicalis
[Pathway:R-DRE-216083] Integrin cell surface interactions - Danio rerio
[Pathway:R-SSC-216083] Integrin cell surface interactions - Sus scrofa
[Pathway:R-BTA-216083] Integrin cell surface interactions - Bos taurus
[Pathway:R-CFA-216083] Integrin cell surface interactions - Canis familiaris
[Pathway:R-RNO-216083] Integrin cell surface interactions - Rattus norvegicus
[Pathway:R-MMU-216083] Integrin cell surface interactions - Mus musculus
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008年05月07日 08:53:37
[InstanceEdit:4088447] Ricard-Blum, Sylvie, 2013年08月13日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-216083
summation
[Summation:215919] The extracellular matrix (ECM) is a network of macro-molecul...
updateTrackers
[UpdateTracker:9864227] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v88:[updateContainedRLE]
[UpdateTracker:9791691] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v27:[addHasEvent]
[UpdateTracker:9791325] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v31:[updateContainedPathway]
[UpdateTracker:9780296] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v63:[removeHasEvent]
[UpdateTracker:9791618] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v28:[updateIndirectRLE]
[UpdateTracker:9787098] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v46:[addLiteratureReference, add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9783535] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v56:[updateContainedRLE]
[UpdateTracker:9785982] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v50:[updateContainedRLE]
[UpdateTracker:9790752] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v33:[updateContainedPathway]
[UpdateTracker:9789861] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v37:[updateContainedPathway]
[UpdateTracker:9787907] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v44:[updateContainedRLE]
[UpdateTracker:9791435] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v30:[updateIndirectRLE]
[UpdateTracker:9790312] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v34:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9776864] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9790891] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v32:[updateContainedPathway]
[UpdateTracker:9789924] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v36:[updateIndirectRLE]
[UpdateTracker:9789477] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v38:[updateContainedRLE]
Referrals
(hasEvent)
[TopLevelPathway:R-HSA-1474244] Extracellular matrix organization
(hasEncapsulatedEvent)
[Pathway:R-HSA-5663220] RHO GTPases Activate Formins
(updatedInstance)
[UpdateTracker:9864227] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v88:[updateContainedRLE]
[UpdateTracker:9791691] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v27:[addHasEvent]
[UpdateTracker:9791325] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v31:[updateContainedPathway]
[UpdateTracker:9780296] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v63:[removeHasEvent]
[UpdateTracker:9791618] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v28:[updateIndirectRLE]
[UpdateTracker:9787098] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v46:[addLiteratureReference, add_removeHasEvent, updateContainedRLE]
[UpdateTracker:9783535] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v56:[updateContainedRLE]
[UpdateTracker:9785982] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v50:[updateContainedRLE]
[UpdateTracker:9790752] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v33:[updateContainedPathway]
[UpdateTracker:9789861] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v37:[updateContainedPathway]
[UpdateTracker:9787907] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v44:[updateContainedRLE]
[UpdateTracker:9791435] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v30:[updateIndirectRLE]
[UpdateTracker:9790312] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v34:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9776864] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9790891] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v32:[updateContainedPathway]
[UpdateTracker:9789924] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v36:[updateIndirectRLE]
[UpdateTracker:9789477] Update Tracker - [Pathway:216083] Integrin cell surface interactions - v38:[updateContainedRLE]
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