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Schema
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Reaction
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Entries
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
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authored
[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日
catalystActivity
[CatalystActivity:209953] calcidiol 1-monooxygenase activity of CYP27B1(?-508) [mitochondrial outer membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:17906] mitochondrial outer membrane
created
[InstanceEdit:209970] Jassal, Bijay, 2008年01月08日
dbId
209868
displayName
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
edited
[InstanceEdit:350358] Jassal, Bijay, 2008年05月19日
eventOf
[Pathway:R-HSA-211916] Vitamins - Homo sapiens
[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm - Homo sapiens
[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Homo sapiens
input
[SimpleEntity:R-ALL-209804] 25(OH)D [cytosol]
[SimpleEntity:R-ALL-70106] H+ [cytosol]
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:215612] Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion
[LiteratureReference:215593] Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells
[LiteratureReference:8963849] Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli
maxDepth
1
modified
[InstanceEdit:10541496] Weiser, Joel, 2025年08月27日
name
CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
orthologousEvent
[Reaction:R-RNO-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Rattus norvegicus
[Reaction:R-DRE-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Danio rerio
[Reaction:R-SSC-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Sus scrofa
[Reaction:R-BTA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Bos taurus
[Reaction:R-CFA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Canis familiaris
[Reaction:R-MMU-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Mus musculus
output
[SimpleEntity:R-ALL-209800] 1,25(OH)2D [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-209766] 25(OH)D translocates from lysosomal lumen to cytosol - Homo sapiens
[Reaction:R-HSA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Homo sapiens
regulatedBy
[NegativeRegulation:9692889] Negative regulation by 'Fru [cytosol]'
releaseDate
2008年06月30日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54
revised
[InstanceEdit:5602271] Jassal, Bijay, 2014年06月23日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-209868
summation
[Summation:215621] The second step in vitamin D activation requires hydroxylati...
updateTrackers
[UpdateTracker:9776772] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v74:[addRegulator]
[UpdateTracker:9786174] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v50:[modifyText]
[UpdateTracker:9780398] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v63:[modifyText]
[UpdateTracker:9782011] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v60:[addLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776772] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v74:[addRegulator]
[UpdateTracker:9786174] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v50:[modifyText]
[UpdateTracker:9780398] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v63:[modifyText]
[UpdateTracker:9782011] Update Tracker - [Reaction:209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - v60:[addLiteratureReference, modifyText]
(normalReaction)
[FailedReaction:R-HSA-5602186] Defective CYP27B1 does not hydroxylate CDL
(hasEvent)
[Pathway:R-HSA-211916] Vitamins
[Pathway:R-HSA-196791] Vitamin D (calciferol) metabolism
(precedingEvent)
[BlackBoxEvent:R-HSA-8963913] 1,25(OH)2D translocates from cytosol to nucleoplasm
[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
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