Reactome Pathway Database

Schema > Reaction > Entries

CYP2R1 25-hydroxylates VD3 to 25(OH)D Show undefined attributes

authored

[InstanceEdit:378946] Jassal, Bijay, 2008年10月01日

catalystActivity

[CatalystActivity:209900] vitamin D3 25-hydroxylase activity of CYP2R1 [endoplasmic reticulum membrane]

category transition

compartment

created [InstanceEdit:209970] Jassal, Bijay, 2008年01月08日

dbId 209845

displayName CYP2R1 25-hydroxylates VD3 to 25(OH)D

edited

eventOf

followingEvent

[BlackBoxEvent:R-HSA-6807242] 25(OH)D translocates from ER membrane to extracellular region - Homo sapiens
[Reaction:R-HSA-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:10948619] Weiser, Joel, 2025年08月27日

name

CYP2R1 25-hydroxylates VD3 to 25(OH)D

orthologousEvent

output

precedingEvent

[BlackBoxEvent:R-HSA-350147] VD3 translocates from extracellular region to ER membrane - Homo sapiens

releaseDate 2008年06月30日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:351775] D'Eustachio, P, 2008年05月28日 08:30:54

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-209845

summation

[Summation:215578] To be functionally active, vitamin D3 (VD3) needs to be dihy...

updateTrackers

Referrals

(updatedInstance)

(normalReaction)

[FailedReaction:R-HSA-5602147] Defective CYP2R1 does not 25-hydroxylate vitamin D

(hasEvent)

(precedingEvent)

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