Reactome Pathway Database

Schema > Reaction > Entries

SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers Show undefined attributes

authored

[InstanceEdit:2065547] May, B, 2012年01月23日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:2065546] May, B, 2012年01月23日

dbId 2065549

displayName SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers

edited

[InstanceEdit:2065547] May, B, 2012年01月23日

eventOf

[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Homo sapiens

followingEvent

[Reaction:R-HSA-2065550] SREBP1A,1C,2 binds Importin beta-1 - Homo sapiens

input

2 × [DefinedSet:R-HSA-1655732] SREBF1A,1C,2 cleaved by S2P [cytosol]

isChimeric false

isInDisease false

isInferred false

literatureReference

[LiteratureReference:1655686] Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers
SREBF1A,1C,2 binds SREBF1A,1C,2 forming dimers

orthologousEvent

output

[Complex:R-HSA-2065548] SREBP1A,1C,2 dimer [cytosol]

precedingEvent

[Reaction:R-HSA-1655851] S2P hydrolyzes SREBP1A,1C,2 - Homo sapiens

releaseDate 2012年09月18日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:2457630] Liang, Guosheng, 2012年08月25日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-2065549

summation

[Summation:2065545] The N-terminal domains of SREBPs (SREBP1A/1C/2, SREBFs) dime...

Referrals

(hasEvent)

[Pathway:R-HSA-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)

(precedingEvent)

[Reaction:R-HSA-2065550] SREBP1A,1C,2 binds Importin beta-1

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