Reactome Pathway Database

Schema > Reaction > Entries

SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers Show undefined attributes

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10541496] Weiser, Joel, 2025年08月27日

dbId 10569193

displayName SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers

eventOf

[Pathway:R-DRE-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF) - Danio rerio

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-2065549] SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers - Homo sapiens

input

2 × [DefinedSet:R-DRE-1655732] SREBF1A,1C,2 cleaved by S2P [cytosol]

isInDisease false

isInferred true

maxDepth 1

name

SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers
SREBF1A,1C,2 binds SREBF1A,1C,2 forming dimers

output

[Complex:R-DRE-2065548] SREBP1A,1C,2 dimer [cytosol]

precedingEvent

[Reaction:R-DRE-1655851] S2P hydrolyzes SREBP1A,1C,2 - Danio rerio

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68323] Danio rerio

stId R-DRE-2065549

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DRE-1655829] Regulation of cholesterol biosynthesis by SREBP (SREBF)

(inferredTo)

[Reaction:R-HSA-2065549] SREBP1A,1C,2 binds SREBP1A,1C,2 forming dimers

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