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Schema
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Reaction
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Entries
AKT1 binds eNOS complex via HSP90
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authored
[InstanceEdit:202104] Hemish, J, 2007年10月19日 18:00:42
catalystActivity
[CatalystActivity:9911126] enzyme-substrate adaptor activity of eNOS:CaM:HSP90 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9911172] enzyme-substrate adaptor activity of eNOS:CaM:HSP90 [plasma membrane] Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:202104] Hemish, J, 2007年10月19日 18:00:42
dbId
202137
displayName
AKT1 binds eNOS complex via HSP90
eventOf
[Pathway:R-HSA-203615] eNOS activation - Homo sapiens
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent
[Reaction:R-HSA-202111] AKT1 phosphorylates eNOS - Homo sapiens
input
[Complex:R-HSA-202105] eNOS:CaM:HSP90 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-198356] p-T308,S473-AKT1 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:202142] Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release
[LiteratureReference:203755] Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex
maxDepth
1
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
AKT1 binds eNOS complex via HSP90
orthologousEvent
[Reaction:R-SPO-202137] AKT1 binds eNOS complex via HSP90 - Schizosaccharomyces pombe
[Reaction:R-DDI-202137] AKT1 binds eNOS complex via HSP90 - Dictyostelium discoideum
[Reaction:R-DME-202137] AKT1 binds eNOS complex via HSP90 - Drosophila melanogaster
[Reaction:R-GGA-202137] AKT1 binds eNOS complex via HSP90 - Gallus gallus
[Reaction:R-RNO-202137] AKT1 binds eNOS complex via HSP90 - Rattus norvegicus
[Reaction:R-MMU-202137] AKT1 binds eNOS complex via HSP90 - Mus musculus
output
[Complex:R-HSA-202113] eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
precedingEvent
[BlackBoxEvent:R-HSA-202132] depalmitoylated eNOS translocates from plasma membrane - Homo sapiens
[Reaction:R-HSA-202144] Caveolin-1 dissociates from eNOS:CaM:HSP90 complex - Homo sapiens
[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:215470] Enikolopov, G, 2008年02月28日 17:52:44
[InstanceEdit:9917333] Hill, David P, 2024年08月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-202137
summation
[Summation:203559] AKT1 is recruited to the M domain of HSP90 (Fontana et al. 2...
updateTrackers
[UpdateTracker:9789074] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v38:[modifyText]
[UpdateTracker:9919438] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v90:[modifyText, removeCatalystActivity]
Referrals
(updatedInstance)
[UpdateTracker:9789074] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v38:[modifyText]
[UpdateTracker:9919438] Update Tracker - [Reaction:202137] AKT1 binds eNOS complex via HSP90 - v90:[modifyText, removeCatalystActivity]
(hasEvent)
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
[Pathway:R-HSA-203615] eNOS activation
(precedingEvent)
[Reaction:R-HSA-202111] AKT1 phosphorylates eNOS
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