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Entries
TCF dependent signaling in response to WNT
Show undefined attributes
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authored
[InstanceEdit:4415000] Rothfels, K, 2013年08月23日
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:7660] nucleoplasm
created
[InstanceEdit:201703] Matthews, L, 2007年09月10日 21:56:08
crossReference
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757966] BioModels Database:BIOMD0000000149
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
201681
diseasePathways
[Pathway:R-HSA-5340588] Signaling by RNF43 mutants - Homo sapiens
[Pathway:R-HSA-5339717] Signaling by LRP5 mutants - Homo sapiens
[Pathway:R-HSA-5545619] XAV939 stabilizes AXIN - Homo sapiens
displayName
TCF dependent signaling in response to WNT
doi
10.3180/REACT_200777.2
edited
[InstanceEdit:4655138] Gillespie, ME, 2013年10月02日
[InstanceEdit:201675] Matthews, L, 2007年09月04日 11:49:29
eventOf
[Pathway:R-HSA-195721] Signaling by WNT - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-1458875] WNT binds to FZD and LRP5/6 - Homo sapiens
[Pathway:R-HSA-201688] WNT mediated activation of DVL - Homo sapiens
[Reaction:R-HSA-1504188] FZD recruits DVL to the receptor complex - Homo sapiens
[Pathway:R-HSA-4641262] Disassembly of the destruction complex and recruitment of AXIN to the membrane - Homo sapiens
[BlackBoxEvent:R-HSA-201669] Beta-catenin translocates to the nucleus - Homo sapiens
[Pathway:R-HSA-201722] Formation of the beta-catenin:TCF transactivating complex - Homo sapiens
[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
[Pathway:R-HSA-4641258] Degradation of DVL - Homo sapiens
[Pathway:R-HSA-4641257] Degradation of AXIN - Homo sapiens
[Reaction:R-HSA-3640872] USP34 deubiquitinates AXIN1,AXIN2 - Homo sapiens
[Pathway:R-HSA-4641263] Regulation of FZD by ubiquitination - Homo sapiens
[Pathway:R-HSA-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Homo sapiens
[Pathway:R-HSA-5368598] Negative regulation of TCF-dependent signaling by DVL-interacting proteins - Homo sapiens
[Reaction:R-HSA-5323545] Canonical WNT signaling through the atypical receptor RYK - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2017年09月27日
literatureReference
[LiteratureReference:1458900] Wnt/beta-catenin signaling: components, mechanisms, and diseases
[LiteratureReference:3238089] The way Wnt works: Components and mechanism
[LiteratureReference:5323469] Wnt/?-catenin signalling: from plasma membrane to nucleus
maxDepth
4
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
TCF dependent signaling in response to WNT
orthologousEvent
[Pathway:R-MMU-201681] TCF dependent signaling in response to WNT - Mus musculus
[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT - Rattus norvegicus
[Pathway:R-CFA-201681] TCF dependent signaling in response to WNT - Canis familiaris
[Pathway:R-BTA-201681] TCF dependent signaling in response to WNT - Bos taurus
[Pathway:R-SSC-201681] TCF dependent signaling in response to WNT - Sus scrofa
[Pathway:R-DRE-201681] TCF dependent signaling in response to WNT - Danio rerio
[Pathway:R-XTR-201681] TCF dependent signaling in response to WNT - Xenopus tropicalis
[Pathway:R-GGA-201681] TCF dependent signaling in response to WNT - Gallus gallus
[Pathway:R-DME-201681] TCF dependent signaling in response to WNT - Drosophila melanogaster
[Pathway:R-CEL-201681] TCF dependent signaling in response to WNT - Caenorhabditis elegans
[Pathway:R-DDI-201681] TCF dependent signaling in response to WNT - Dictyostelium discoideum
releaseDate
2014年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5251465] Rajakulendran, Nishani, 2014年01月22日
[InstanceEdit:5323527] van Amerongen, R, 2014年02月14日
[InstanceEdit:5368564] Kikuchi, Akira, 2014年04月22日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-201681
summation
[Summation:3772454] 19 WNT ligands and 10 FZD receptors have been identified in ...
updateTrackers
[UpdateTracker:9782399] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v59:[updateIndirectRLE]
[UpdateTracker:9780779] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v62:[updateIndirectRLE]
[UpdateTracker:9781279] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v61:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9785091] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v52:[updateContainedPathway]
[UpdateTracker:9786434] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v49:[addHasEvent, updateContainedPathway, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-195721] Signaling by WNT
(hasEncapsulatedEvent)
[Pathway:R-HSA-9772755] Formation of WDR5-containing histone-modifying complexes
[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking
[Pathway:R-HSA-3858494] Beta-catenin independent WNT signaling
[Pathway:R-HSA-8853884] Transcriptional Regulation by VENTX
(normalPathway)
[Pathway:R-HSA-5340588] Signaling by RNF43 mutants
[Pathway:R-HSA-5339717] Signaling by LRP5 mutants
[Pathway:R-HSA-5545619] XAV939 stabilizes AXIN
(updatedInstance)
[UpdateTracker:9782399] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v59:[updateIndirectRLE]
[UpdateTracker:9780779] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v62:[updateIndirectRLE]
[UpdateTracker:9781279] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v61:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9785091] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v52:[updateContainedPathway]
[UpdateTracker:9786434] Update Tracker - [Pathway:201681] TCF dependent signaling in response to WNT - v49:[addHasEvent, updateContainedPathway, updateIndirectRLE]
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