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Schema
>
BlackBoxEvent
>
Entries
Active ALK recruits PI3K
Show undefined attributes
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authored
[InstanceEdit:201559] Jassal, B, 2007年08月21日 12:55:28
category
uncertain
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:201539] Jassal, B, 2007年08月21日 12:50:53
dbId
201515
displayName
Active ALK recruits PI3K
edited
[InstanceEdit:201559] Jassal, B, 2007年08月21日 12:55:28
eventOf
[Pathway:R-HSA-201556] Signaling by ALK - Homo sapiens
followingEvent
[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK - Homo sapiens
input
[CandidateSet:R-HSA-9850879] Active ALK dimer [plasma membrane]
[Complex:R-HSA-74693] PI3K [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9699737] Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway
[LiteratureReference:201541] Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
[LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer
[LiteratureReference:201494] Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin
[LiteratureReference:9667900] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Active ALK recruits PI3K
orthologousEvent
[BlackBoxEvent:R-GGA-201515] Active ALK recruits PI3K - Gallus gallus
[BlackBoxEvent:R-DRE-201515] Active ALK recruits PI3K - Danio rerio
[BlackBoxEvent:R-SSC-201515] Active ALK recruits PI3K - Sus scrofa
[BlackBoxEvent:R-BTA-201515] Active ALK recruits PI3K - Bos taurus
[BlackBoxEvent:R-CFA-201515] Active ALK recruits PI3K - Canis familiaris
[BlackBoxEvent:R-RNO-201515] Active ALK recruits PI3K - Rattus norvegicus
[BlackBoxEvent:R-MMU-201515] Active ALK recruits PI3K - Mus musculus
output
[Complex:R-HSA-9699995] Active ALK:PI3K [plasma membrane]
precedingEvent
[Reaction:R-HSA-201521] ALK autophosphorylation - Homo sapiens
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2021年06月09日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9729891] Inghirami, Giorgio, 2021年05月04日
[InstanceEdit:9852935] Turner, Suzanne, 2023年11月08日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-201515
summation
[Summation:201538] Activated ALK in the form of NPM-ALK recruits PI3K. Binding ...
updateTrackers
[UpdateTracker:9853263] Update Tracker - [BlackBoxEvent:201515] Active ALK recruits PI3K - v87:[addLiteratureReference, add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9853263] Update Tracker - [BlackBoxEvent:201515] Active ALK recruits PI3K - v87:[addLiteratureReference, add_removeInput, modifyText]
(normalReaction)
[Reaction:R-HSA-9712083] ALK mutants bind PI3KCA
(hasEvent)
[Pathway:R-HSA-201556] Signaling by ALK
(precedingEvent)
[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK
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