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Schema
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Reaction
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Entries
TORC2 (mTOR) phosphorylates AKT at S473
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日
catalystActivity
[CatalystActivity:198624] protein serine/threonine kinase activity of TORC2 complex [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:198616] Jassal, B, 2007年06月29日 07:57:48
dbId
198640
displayName
TORC2 (mTOR) phosphorylates AKT at S473
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
eventOf
[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent
[Reaction:R-HSA-2317314] AKT binds PDPK1 - Homo sapiens
input
[Complex:R-HSA-2317329] AKT:PIP3 [plasma membrane]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:199373] Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
[LiteratureReference:199317] Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
maxDepth
1
modified
[InstanceEdit:11033291] Weiser, Joel, 2025年08月28日
name
TORC2 (mTOR) phosphorylates AKT at S473
orthologousEvent
[Reaction:R-SCE-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Saccharomyces cerevisiae
[Reaction:R-SPO-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Schizosaccharomyces pombe
[Reaction:R-DDI-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Dictyostelium discoideum
[Reaction:R-CEL-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Caenorhabditis elegans
[Reaction:R-DME-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Drosophila melanogaster
[Reaction:R-GGA-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Gallus gallus
[Reaction:R-RNO-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Rattus norvegicus
[Reaction:R-MMU-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-2317310] p-S-AKT:PIP3 [plasma membrane]
precedingEvent
[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-199457] Negative regulation by 'AKT:PIP3:THEM4/TRIB3 [plasma membrane]'
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007年11月08日 15:39:37
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
revised
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-198640
summation
[Summation:202051] Under conditions of growth and mitogen stimulation S473 phos...
updateTrackers
[UpdateTracker:9789479] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v38:[modifyText]
[UpdateTracker:9791333] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v31:[modifyText]
[UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9789479] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v38:[modifyText]
[UpdateTracker:9791333] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v31:[modifyText]
[UpdateTracker:9788384] Update Tracker - [Reaction:198640] TORC2 (mTOR) phosphorylates AKT at S473 - v42:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeRegulator, modifyText]
(hasEvent)
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(precedingEvent)
[Reaction:R-HSA-2317314] AKT binds PDPK1
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