Reactome Pathway Database

Schema > Reaction > Entries

TORC2 (mTOR) phosphorylates AKT at S473 Show undefined attributes

catalystActivity

[CatalystActivity:10695191] protein serine/threonine kinase activity of TORC2 complex [cytosol]

category transition

compartment

created [InstanceEdit:10680101] Weiser, Joel, 2025年08月27日

dbId 10695199

displayName TORC2 (mTOR) phosphorylates AKT at S473

eventOf

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-GGA-2317314] AKT binds PDPK1 - Gallus gallus

inferredFrom

[Reaction:R-HSA-198640] TORC2 (mTOR) phosphorylates AKT at S473 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

TORC2 (mTOR) phosphorylates AKT at S473

output

precedingEvent

[Reaction:R-GGA-2317332] PIP3 recruits AKT to the membrane - Gallus gallus

regulatedBy

[NegativeRegulation:10695200] Negative regulation by 'AKT:PIP3:THEM4/TRIB3 [plasma membrane]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49591] Gallus gallus

stId R-GGA-198640

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

[Reaction:R-GGA-2317314] AKT binds PDPK1

(inferredTo)

[Reaction:R-HSA-198640] TORC2 (mTOR) phosphorylates AKT at S473

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