Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
CandidateSet
>
Entries
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
Show undefined attributes
Go to Details
compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-8864106] Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] - Homo sapiens
[Complex:R-NUL-1985735] Shc1:Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-8864105] PTPN18 binds ERBB2:EGFR heterodimers - Homo sapiens
[Reaction:R-HSA-1251944] PLCG1 binds to p-ERBB2:p-EGFR - Homo sapiens
[Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer - Homo sapiens
[Reaction:R-NUL-1248744] Shc1 binds phosphorylated ERBB2:EGFR heterodimers - Homo sapiens
[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR - Homo sapiens
created
[InstanceEdit:1963565] Orlic-Milacic, M, 2011年11月03日
dbId
1963587
displayName
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
hasCandidate
[Complex:R-HSA-1248703] EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] - Homo sapiens
hasMember
[Complex:R-HSA-1963593] EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane] - Homo sapiens
inDisease
false
inferredTo
[CandidateSet:R-MMU-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Mus musculus
[CandidateSet:R-RNO-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Rattus norvegicus
[CandidateSet:R-CFA-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Canis familiaris
[GenomeEncodedEntity:R-BTA-1963587] Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Bos taurus
[CandidateSet:R-SSC-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Sus scrofa
[GenomeEncodedEntity:R-DRE-1963587] Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Danio rerio
[GenomeEncodedEntity:R-XTR-1963587] Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Xenopus tropicalis
[CandidateSet:R-GGA-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Gallus gallus
[CandidateSet:R-DME-1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - Drosophila melanogaster
[CandidateSet:R-CEL-1963588] p-ERBB2 heterodimers [plasma membrane] - Caenorhabditis elegans
maxDepth
4
modified
[InstanceEdit:2448604] Orlic-Milacic, M, 2012年08月13日
name
Phosphorylated ERBB2:EGFR heterodimers
producedByEvent
[Reaction:R-HSA-1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2 - Homo sapiens
schemaClass
CandidateSet
species
[Species:48887] Homo sapiens
stId
R-HSA-1963587
updateTrackers
[UpdateTracker:9879418] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v44:[updateContainedMemberOrCandidate]
[UpdateTracker:9872946] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872089] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v41:[updateContainedMemberOrCandidate]
[UpdateTracker:9894632] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v57:[updateContainedMemberOrCandidate]
Referrals
(updatedInstance)
[UpdateTracker:9879418] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v44:[updateContainedMemberOrCandidate]
[UpdateTracker:9872946] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v42:[removeCompartment]
[UpdateTracker:9872089] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v41:[updateContainedMemberOrCandidate]
[UpdateTracker:9894632] Update Tracker - [CandidateSet:1963587] Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] - v57:[updateContainedMemberOrCandidate]
(normalEntity)
[EntityFunctionalStatus:9665448] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665038] gain_of_function of p-6Y-ERBB2 KD mutants (PLCG1):EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9664928] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9664998] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665923] gain_of_function of p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane]
[EntityFunctionalStatus:9665918] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR [plasma membrane]
(input)
[Reaction:R-HSA-8864105] PTPN18 binds ERBB2:EGFR heterodimers
[Reaction:R-HSA-1250488] GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
[Reaction:R-NUL-1248744] Shc1 binds phosphorylated ERBB2:EGFR heterodimers
[Reaction:R-HSA-1251944] PLCG1 binds to p-ERBB2:p-EGFR
[Reaction:R-HSA-1306963] Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
(hasComponent)
[Complex:R-HSA-8864106] Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane]
[Complex:R-NUL-1985735] Shc1:Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
[Complex:R-HSA-1250505] EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-1251942] EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane]
[Complex:R-HSA-1306958] EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane]
(output)
[Reaction:R-HSA-1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル