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25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
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authored
[InstanceEdit:191331] Jassal, Bijay, 2007年01月19日
catalystActivity
[CatalystActivity:192350] 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity of HSD17B4 dimer [peroxisomal matrix]
category
transition
compartment
[Compartment:17951] peroxisomal matrix
created
[InstanceEdit:193476] D'Eustachio, P, 2007年02月19日 17:36:33
dbId
193535
displayName
25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
edited
[InstanceEdit:193475] D'Eustachio, P, 2007年02月17日 19:40:28
eventOf
[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Homo sapiens
followingEvent
[Reaction:R-HSA-193508] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA - Homo sapiens
input
[SimpleEntity:R-ALL-193459] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA [peroxisomal matrix]
[SimpleEntity:R-ALL-141343] H2O [peroxisomal matrix]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:192311] Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase
maxDepth
1
modified
[InstanceEdit:10948619] Weiser, Joel, 2025年08月27日
name
25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA + H2O => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
orthologousEvent
[Reaction:R-DDI-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Dictyostelium discoideum
[Reaction:R-CEL-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Caenorhabditis elegans
[Reaction:R-DME-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Drosophila melanogaster
[Reaction:R-GGA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Gallus gallus
[Reaction:R-BTA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Bos taurus
[Reaction:R-CFA-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Canis familiaris
[Reaction:R-RNO-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Rattus norvegicus
[Reaction:R-MMU-193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - Mus musculus
output
[SimpleEntity:R-ALL-193732] 3,7,24THCA-CoA [peroxisomal matrix]
precedingEvent
[Reaction:R-HSA-193369] 25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA - Homo sapiens
releaseDate
2007年05月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:197117] D'Eustachio, P, 2007年04月30日 14:43:26
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-193535
summation
[Summation:193379] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is ...
updateTrackers
[UpdateTracker:9779891] Update Tracker - [Reaction:193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - v64:[add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9779891] Update Tracker - [Reaction:193535] 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA - v64:[add_removeOutput]
(hasEvent)
[Pathway:R-HSA-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)
[Reaction:R-HSA-193508] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
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