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Schema
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Pathway
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Entries
Cellular hexose transport
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authored
[InstanceEdit:189111] D'Eustachio, P, 2006年11月03日 14:36:07
created
[InstanceEdit:189226] D'Eustachio, P, 2006年11月04日 20:44:47
crossReference
[DatabaseIdentifier:12758024] BioModels Database:BIOMD0000000570
dbId
189200
deleted
[Deleted:8981591] Deletion of instance: 428776
[Deleted:8981592] Deletion of instance: 428790
[Deleted:8981595] Deletion of instance: 428808
[Deleted:8981599] Deletion of instance: 70153
diseasePathways
[Pathway:R-HSA-5656364] Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) - Homo sapiens
[Pathway:R-HSA-5658208] Defective SLC5A2 causes renal glucosuria (GLYS1) - Homo sapiens
[Pathway:R-HSA-5619068] Defective SLC2A10 causes arterial tortuosity syndrome (ATS) - Homo sapiens
[Pathway:R-HSA-5619047] Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) - Homo sapiens
[Pathway:R-HSA-5619043] Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) - Homo sapiens
displayName
Cellular hexose transport
doi
10.3180/REACT_9441.1
eventOf
[Pathway:R-HSA-425407] SLC-mediated transmembrane transport - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:20541] hexose transmembrane transport
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-5339524] GLUT1 (SLC2A1) tetramer transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-450088] GLUT1 tetramer binds 4xATP - Homo sapiens
[Reaction:R-HSA-450092] GLUT1:ATP tetramer dissociates to GLUT1 tetramer and 4xATP - Homo sapiens
[Reaction:R-HSA-8981574] GLUT2 (SLC2A2) tetramer transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-450095] GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-8981564] GLUT3 (SLC2A3) tetramer transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-8981570] GLUT4 (SLC2A4) tetramer transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-429036] SLC2A9 transports Fru, Glc, urate - Homo sapiens
[Reaction:R-HSA-429094] SLC2A6,8,10,12 transport Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-428779] GLUT7 and GLUT11 transport glucose and fructose - Homo sapiens
[Reaction:R-HSA-8981553] GLUT14 (SLC2A14) tetramer transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-9728150] SLC5A2 binds gliflozins - Homo sapiens
[Reaction:R-HSA-8876283] SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-8875902] SLC45A3 transports Glc from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-8876319] SLC50A1 transports Glc from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-429613] SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol - Homo sapiens
[Reaction:R-HSA-429567] Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:428798] The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
[LiteratureReference:191107] Apical GLUT2: a major pathway of intestinal sugar absorption
[LiteratureReference:428778] Functional properties and genomics of glucose transporters
[LiteratureReference:428773] Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
[LiteratureReference:189251] Surprising versatility of Na+-glucose cotransporters: SLC5
maxDepth
2
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Cellular hexose transport
orthologousEvent
[Pathway:R-MMU-189200] Cellular hexose transport - Mus musculus
[Pathway:R-RNO-189200] Cellular hexose transport - Rattus norvegicus
[Pathway:R-CFA-189200] Cellular hexose transport - Canis familiaris
[Pathway:R-BTA-189200] Cellular hexose transport - Bos taurus
[Pathway:R-SSC-189200] Cellular hexose transport - Sus scrofa
[Pathway:R-DRE-189200] Cellular hexose transport - Danio rerio
[Pathway:R-XTR-189200] Cellular hexose transport - Xenopus tropicalis
[Pathway:R-GGA-189200] Cellular hexose transport - Gallus gallus
[Pathway:R-DME-189200] Cellular hexose transport - Drosophila melanogaster
[Pathway:R-CEL-189200] Cellular hexose transport - Caenorhabditis elegans
[Pathway:R-DDI-189200] Cellular hexose transport - Dictyostelium discoideum
[Pathway:R-SPO-189200] Cellular hexose transport - Schizosaccharomyces pombe
[Pathway:R-SCE-189200] Cellular hexose transport - Saccharomyces cerevisiae
[Pathway:R-PFA-189200] Cellular hexose transport - Plasmodium falciparum
releaseDate
2006年01月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:191112] Wright, EM, 2007年01月15日 21:00:45
[InstanceEdit:433651] He, L, 2009年08月24日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-189200
summation
[Summation:189232] Two gene families are responsible for glucose transport in h...
updateTrackers
[UpdateTracker:9790922] Update Tracker - [Pathway:189200] Cellular hexose transport - v32:[addHasEvent, addLiteratureReference, modifyText]
[UpdateTracker:9792015] Update Tracker - [Pathway:189200] Cellular hexose transport - v24:[updateContainedRLE]
[UpdateTracker:9780963] Update Tracker - [Pathway:189200] Cellular hexose transport - v61:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9791477] Update Tracker - [Pathway:189200] Cellular hexose transport - v30:[updateContainedRLE]
[UpdateTracker:9774820] Update Tracker - [Pathway:189200] Cellular hexose transport - v81:[addHasEvent]
[UpdateTracker:9782925] Update Tracker - [Pathway:189200] Cellular hexose transport - v58:[addHasEvent]
[UpdateTracker:9782307] Update Tracker - [Pathway:189200] Cellular hexose transport - v59:[updateContainedRLE]
[UpdateTracker:9780854] Update Tracker - [Pathway:189200] Cellular hexose transport - v62:[modifyText]
Referrals
(hasEvent)
[Pathway:R-HSA-425407] SLC-mediated transmembrane transport
(normalPathway)
[Pathway:R-HSA-5656364] Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)
[Pathway:R-HSA-5658208] Defective SLC5A2 causes renal glucosuria (GLYS1)
[Pathway:R-HSA-5619068] Defective SLC2A10 causes arterial tortuosity syndrome (ATS)
[Pathway:R-HSA-5619047] Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)
[Pathway:R-HSA-5619043] Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
(replacementInstances)
[Deleted:8981591] Deletion of instance: 428776
[Deleted:8981592] Deletion of instance: 428790
[Deleted:8981599] Deletion of instance: 70153
[Deleted:8981595] Deletion of instance: 428808
(updatedInstance)
[UpdateTracker:9790922] Update Tracker - [Pathway:189200] Cellular hexose transport - v32:[addHasEvent, addLiteratureReference, modifyText]
[UpdateTracker:9792015] Update Tracker - [Pathway:189200] Cellular hexose transport - v24:[updateContainedRLE]
[UpdateTracker:9780963] Update Tracker - [Pathway:189200] Cellular hexose transport - v61:[addLiteratureReference, add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9791477] Update Tracker - [Pathway:189200] Cellular hexose transport - v30:[updateContainedRLE]
[UpdateTracker:9774820] Update Tracker - [Pathway:189200] Cellular hexose transport - v81:[addHasEvent]
[UpdateTracker:9782925] Update Tracker - [Pathway:189200] Cellular hexose transport - v58:[addHasEvent]
[UpdateTracker:9782307] Update Tracker - [Pathway:189200] Cellular hexose transport - v59:[updateContainedRLE]
[UpdateTracker:9780854] Update Tracker - [Pathway:189200] Cellular hexose transport - v62:[modifyText]
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